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Objectives: To investigate the relative contribution of body composition (lean and fat) to bone mineral density (BMD), 196 premenopausal and 128 postmenopausal Japanese women were enrolled. Methods: Total fat mass, total lean mass, lumbar BMD (L2–L4), and total body BMD were measured by dual-energy X-ray absorptiometry (DEXA, Hologic QDR 2000, MA, USA). Physical characteristics were also recorded for each subject. Correlation between BMD and variables were calculated for each of the two groups in single and stepwise regression analyses. Results: Total lean mass was significantly higher in premenopausal women than postmenopausal women (P < 0.0001), while body weight, body mass index, and total fat mass were not different between the two groups. In stepwise regression analysis, total lean mass was the most powerful determinant of lumbar BMD and total body BMD in premenopausal women. In postmenopausal women, total fat mass was the most significant determinant of lumbar BMD, while total lean mass was the most significant determinant of total body BMD. Conclusions: These findings suggest that there is a difference between pre- and postmenopausal women in the relative contribution of lean and fat mass. Total lean mass is the most significant determinant of BMD in premenopausal women. On the other hand, total fat mass may have some advantages in maintaining BMD in postmenopausal women.
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- Relation between body size and bone mineral density with special reference to sex hormone and calcium regulating hormones in elderly females.Endocrinol Jpn. 1991; 38: 343-349
- Factor associated with appendicular bone mass in older women. The study of osteoporotic fractures research group.Ann Intern Med. 1993; 118: 657-665
- Regular exercise dissociation fat mass and bone density in premenopausal women.J Clin Endocrinol Metab. 1995; 80: 1764-1768
- Obesity as a determinant of regional bone mineral density.J Nutr Sci Vitaminol. 1991; 37: 65-70
- An epidemiological study of hip fracture in postmenopausal women.Am J Epidemiol. 1982; 116: 141-148
- Joint influence of fat and lean body composition compartment on femoral bone mineral density in premenopausal women.Am J Epidemiol. 1992; 136: 141-148
- Dual-energy X-ray absorptiometry for total-body and regional bonemineral and soft tissue composition.Am J Clin Nutr. 1990; 51: 1106-1112
- Skeletal and bodycomposition effect of anorexia nervosa.Am J Clin Nutr. 1990; 52: 438-441
- Sex- and menopause-associated changes in body-fat distribution.Am J Clin Nutr. 1992; 55: 950-954
- Total body nitrogen in health and disease: effect of age, weight, height, and sex.J Lab Clin Med. 1982; 99: 917-926
- Physical activity and bone mass: exercise in futility.Bone Miner. 1993; 21: 89-112
- Lean body mass and lumbar spine bone mineral density in premenopausal women.Med Sci Sport Exerc. 1993; 25: S153
- Bone mass and anthropometric measurement in adult females.Bone Miner. 1990; 11: 101-109
- Determinants of total body and regional bone mineral density in normal postmenopausal women — a key role for fat mass.J Clin Endocrinol Metab. 1992; 75: 45-51
- Circulating insulin levels are related to bone density in normal postmenopausal women.Am J Physiol. 1993; 265: 655-659
- Relationship of body composition, muscle strength, and aerobic capacity to bone mineral density in older men and women.J Bone Miner Res. 1989; 4: 421-432
- Effect of disuse on bone mineral content, lean mass, and fat mass in osteoarthritic patients.J Bone Miner Metab. 1996; 14: 167-170
- Muscle strength, physical fitness, and weight but not age predict femoral neck bone mass.J Bone Miner Res. 1989; 4: 441-448
Accepted: January 24, 1997
Received in revised form: November 4, 1996
Received: August 26, 1996
© 1997 Published by Elsevier Inc.