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Abstract
Objectives: To investigate the relative contribution of body composition (lean and fat) to bone
mineral density (BMD), 196 premenopausal and 128 postmenopausal Japanese women were
enrolled. Methods: Total fat mass, total lean mass, lumbar BMD (L2–L4), and total body BMD were measured
by dual-energy X-ray absorptiometry (DEXA, Hologic QDR 2000, MA, USA). Physical characteristics
were also recorded for each subject. Correlation between BMD and variables were calculated
for each of the two groups in single and stepwise regression analyses. Results: Total lean mass was significantly higher in premenopausal women than postmenopausal
women (P < 0.0001), while body weight, body mass index, and total fat mass were not different
between the two groups. In stepwise regression analysis, total lean mass was the most
powerful determinant of lumbar BMD and total body BMD in premenopausal women. In postmenopausal
women, total fat mass was the most significant determinant of lumbar BMD, while total
lean mass was the most significant determinant of total body BMD. Conclusions: These findings suggest that there is a difference between pre- and postmenopausal
women in the relative contribution of lean and fat mass. Total lean mass is the most
significant determinant of BMD in premenopausal women. On the other hand, total fat
mass may have some advantages in maintaining BMD in postmenopausal women.
Keywords
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Article info
Publication history
Accepted:
January 24,
1997
Received in revised form:
November 4,
1996
Received:
August 26,
1996
Identification
Copyright
© 1997 Published by Elsevier Inc.
