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Abstract
Objective: To evaluate endometrial blood flow characteristics in response to estrogen replacement
therapy (ERT) and tibolone in postmenopausal women and to correlate the resistance
index (RI) with plasma estradiol levels. Materials and methods: Transvaginal color Doppler ultrasound examinations were performed in 72 asymptomatic,
postmenopausal women who demonstrated endometrial thickness ≤ 5 mm. Thirty-six women
receiving tibolone and 36 patients receiving ERT by a vaginal ring comprised the study
groups. Results: All postmenopausal women treated with tibolone or ERT showed continuous forward end-diastolic
flow. The lowest RI was obtained in women with the vaginal ring inserted. The plasma
concentrations of estradiol were found to be significantly higher in the vaginal ring
group than those of tibolone. Conclusions: The data observed suggest that ERT and tibolone modify normal postmenopausal endometrial
perfusion. Tibolone had a weaker estrogenic effect on endometrial blood flow resistance,
and vaginal ring treatment enhanced endometrial blood perfusion through vasodilatation.
Keywords
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Article info
Publication history
Accepted:
January 3,
1997
Received in revised form:
December 9,
1996
Received:
July 2,
1996
Identification
Copyright
© 1997 Published by Elsevier Inc.
