This paper is only available as a PDF. To read, Please Download here.
Abstract
Objectives: The aim of the study was to obtain information on the possible relationship between
impaired ovarian function and risk factors for cardiovascular disease. Material and methods: Serum lipid levels, plasma fibrinolytic potential and histological and biochemical
changes in the intima of the uterine artery were investigated in premenopausal women
with irregular menstrual cycles, and the results were compared with those from regularly
menstruating women. In addition, the same parameters were studied in postmenopausal
women on hormone replacement therapy (HRT) and in postmenopausal women who had never
used HRT. In total 64 patients undergoing hysterectomy for benign reasons were included
the study. Results: Plasma fibrinogen concentration was significantly higher in irregularly menstruating
women as compared with women with regular cycles. In women with irregular cycles thickened
or sclerotic arterial intima was a significantly more common finding as compared with
regularly menstruating women. A significant positive correlation was observed between
plasma fibrinogen concentration and intimal esterified cholesterol content in women
with thickened or sclerotic uterine artery. Conclusions: These data suggest an important role for normal ovarian function in the prevention
of atherosclerosis.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to MaturitasAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Menopause and the risk of coronary heart disease in women.N Engl J Med. 1987; 316: 1105-1110
- Estrogen and coronary heart disease in women.JAMA. 1991; 265: 1861-1867
- Age at menopause as a risk factor for cardiovascular mortality.Lancet. 1996; 347: 714-718
- Hemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study.Lancet. 1986; 2: 533-537
- Hormone replacement therapy and atherosclerosis.J Reprod Med. 1995; 40: 267-272
- Improved method for separation of total HDL cholesterol and subclasses.Clin Chem. 1989; 35: 1086
- Estimation of concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge.Clin Chem. 1972; 18: 499-502
- Protein measurement with the Folin phenol reagent.J Biol Chem. 1951; 193: 265-275
- Total cholesterol concentration and mortality at a relatively young age: Do men and women differ?.Br Med J. 1995; 311: 779-783
- Perimenopausal changes in serum lipids and lipoproteins: A 7-years longitudinal study.Maturitas. 1995; 22: 193-197
- Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosecerosis.Arterioscler Thromb. 1993; 13: 1829-1836
- Fate of fibrinogen in human arterial intima.Arteriosclerosis. 1990; 10: 263-275
- Fibrinogen and Factor VII in the prediction of coronary risk: Results from the PROCAM study in healthy men.Arterioscler Thromb. 1994; 14: 54-59
- Association between increased estrogen status and increased fibrinolytic potential in the Framingham Offspring study.Circulation. 1995; 91: 1952-1958
- The endocrinology of the menopausal transition: A cross-sectional study of a population-based sample.J Clin Endocrinol Metab. 1995; 80: 3537-3545
- Phospholipases in arterial tissue IV The role of phosphatide acyl hydrolase, lysophosphatide acyl hydrolase, and sphingomyelin choline phosphorylase in the regulation of phospholipid composition in the normal human aorta with age.J Clin Invest. 1969; 48: 2320-2322
- Cholesterol, triglyceride, and phospholipid content of intima, media, and atherosclerotic fatty streak in human thoracic aorta.J Clin Invest. 1966; 45: 513-523
- The relationship between plasma and tissue lipids in human atherosclerosis.Adv Lipid Res. 1974; 12: 1-49
- Role of oxidised low density lipoprotein in atherogenesis.Br Heart J. 1993; 69 (Suppl): S12-S18
- Preatheroma phase of coronary atherosclerosis in man.Exp Mol Pathol. 1964; 3: 475-479
- Coronary artery fine structure in rhesus monkeys: The early atherosclerotic lesion and its progression.in: Strong JP Atherosclerosis in Primates. Karger, Basel1976: 359-395
Article info
Publication history
Accepted:
March 27,
1997
Received in revised form:
March 17,
1997
Received:
June 17,
1996
Identification
Copyright
© 1997 Published by Elsevier Inc.
