The World Health Organization (WHO) has declared that antimicrobial resistance (AMR)
is one of the top 10 global public health threats confronting humankind. In low- and
middle-income countries (LMICs), which are home to about 84 % of the world's population,
all-age death rates due to AMR are the highest, implying AMR is not only a global
menace but a particularly grave concern for LMICs [
[1]
]. The burden of infections and AMR is high in the elderly population in particular,
due to frail immunity, deteriorating organ functions, and chronic comorbidities. Poor
treatment outcomes due to accelerated disease progression and slow recovery are the
key challenges in the management of AMR in the elderly [
[2]
]. Of note, camouflaged physical signs in the elderly and the lack of adequate clinical
experts pose diagnostic challenges in LMICs. In these countries, the AMR burden is
highest due to the high frequency of critical infections, inadequate microbiological
testing infrastructure, inappropriate use of antibiotics, inadequate access to second-
and third-line antibiotics, poverty, poor sanitation and hygiene, data paucity, and
weak regulations [
[3]
]. Although research and development of novel antimicrobial agents is one of the pivotal
strategies to mitigate the AMR burden, the progress in the development of novel and
effective antimicrobials is still inadequate [
[4]
].Keywords
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References
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- Knowledge and expectations on antibiotic use among older adults in Malaysia: a cross-sectional survey.Geriatrics. 2019 Oct 25; 4: 61
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- Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria.Theranostics. 2021; 11: 4910
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Article info
Publication history
Published online: December 01, 2022
Accepted:
November 20,
2022
Received:
November 17,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier B.V. All rights reserved.
