- •Higher baseline estrone levels were found to be associated with poorer global cognition, auditory attention and working memory, visual attention, and executive function, but not working memory.
- •Higher levels of baseline 17β-E2 were associated with poorer cognitive performance, with marginal significance at baseline in speeded language and mental flexibility, while other hormone levels were not associated with cognition.
- •Controlling for all treatments, hormone levels at baseline and at month 48 did not have any significant correlation with cognitive trajectories over time.
- •These results suggest that postmenopausal hormone therapy may not affect the projection of cognitive performance.
- •These findings do, however, support the hypothesis that endogenous estrone levels, estrone metabolism, or secondary factors associated with elevations in estrone may affect various cognitive domains, regardless of hormone therapy.
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