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The association between grip strength and incident carotid atherosclerosis in middle-aged and older adults: The TCLSIH cohort study

  • Author Footnotes
    1 Co-first author with equal contribution.
    Bei Zhang
    Footnotes
    1 Co-first author with equal contribution.
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Author Footnotes
    1 Co-first author with equal contribution.
    Xuena Wang
    Footnotes
    1 Co-first author with equal contribution.
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
    Search for articles by this author
  • Yeqing Gu
    Correspondence
    Corresponding authors at: School of Public Health of Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
    Affiliations
    Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
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  • Qing Zhang
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Li Liu
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Ge Meng
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Hongmei Wu
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Shunming Zhang
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Tingjing Zhang
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Huiping Li
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Juanjuan Zhang
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Shaomei Sun
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Xing Wang
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Ming Zhou
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Qiyu Jia
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Kun Song
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Jian Huang
    Affiliations
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China
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  • Junsheng Huo
    Affiliations
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China
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  • Bing Zhang
    Affiliations
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China
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  • Gangqiang Ding
    Affiliations
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China
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  • Kaijun Niu
    Correspondence
    Corresponding authors at: School of Public Health of Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
    Affiliations
    School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China

    Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China

    Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China

    Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China
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  • Author Footnotes
    1 Co-first author with equal contribution.
Published:September 29, 2022DOI:https://doi.org/10.1016/j.maturitas.2022.09.008

      Highlights

      • Enhanced muscle strength and muscle-derived cytokines (myokines) are linked with atherosclerosis.
      • Higher absolute grip strength was associated with a lower incidence of carotid atherosclerosis.
      • Higher weight-adjusted grip strength was associated with a lower incidence of carotid atherosclerosis.

      Abstract

      Objectives

      Atherosclerosis has become a leading public health problem. Previous studies suggest that enhanced muscle strength and muscle-derived cytokines (myokines) are linked with atherosclerosis. However, no previous prospective study has examined the relationship between grip strength (GS) and carotid atherosclerosis (CAS) in middle-aged and older adults. We therefore designed a cohort study to investigate the association between GS and the incidence of CAS in a population aged 45 years and over.

      Methods

      The cohort study (n = 1258; follow-up range: 1–6 years, median: 4.0 years, age range: 45–85 years) was performed from 2013 to 2019 in Tianjin, China. CAS was measured using a carotid artery B-mode ultrasound system and defined by increased carotid intima-media thickness and plaques. GS was measured using a handheld digital dynamometer. Adjusted Cox proportional hazards regression models were used to assess the association between quartiles of GS and CAS.

      Results

      The incidence of CAS was 122 cases per 1000 person-years. In the final multivariable models, the adjusted hazard ratios (HRs) [95 % confidence interval (CI)] for CAS across quartiles of weight-adjusted GS (Q1-Q4) were as follows: 1.00 (reference), 0.82 (0.63, 1.06), 0.92 (0.71, 1.19), 0.69 (0.52, 0.91) and the HRs (95 % CI) across quartiles of GS (Q1-Q4) were as follows: 1.00 (reference), 1.06 (0.83, 1.36), 0.78 (0.59, 1.02), 0.76 (0.58, 0.995). For one unit and one standard deviation (SD) increase in weight-adjusted GS, the adjusted HRs (95 % CI) of CAS were 0.16 (0.05, 0.52) and 0.82 (0.72, 0.93), respectively. For one unit and one SD increase in GS, the adjusted HRs (95 % CI) of CAS were 0.98 (0.96, 0.995), and 0.47 (0.26, 0.83), respectively.

      Conclusions

      Higher GS was associated with a lower incidence of carotid atherosclerosis in middle-aged and older adults. Further studies are required to clarify the causality.

      Keywords

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