Highlights
- •The evidence indicates that intentional weight loss offers improvements in health.
- •We reviewed the association between intentional weight loss and mortality in middle-aged and older adults (i.e., those aged 50 years or more).
- •No clear association was found between losing weight intentionally and mortality in middle-aged and older adults.
- •More information is required in this area, as account needs to be taken of the many confounding factors.
Abstract
The literature on the association between intentional weight loss and mortality rates
has yielded controversial results, especially when it comes to older groups. The aim
of the present narrative review was the critical evaluation of studies exploring the
association between intentional weight loss and mortality in middle-aged and older
adults (i.e., those aged 50 years or more). The majority of the longitudinal studies
identified concluded that losing weight intentionally is not associated with mortality
in middle-aged and older adults. However, when it comes to younger adults at the recruitment
point, the studies have yielded more mixed results. In any case, more well-designed
longitudinal studies and randomized clinical trials are needed in the area, with long
follow-up periods and taking into account the underlying disease states.
Keywords
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References
- Benefits of weight loss of 10% or more in patients with overweight or obesity: a review.Obesity (Silver Spring). 2022; 30: 802-840
- Weight loss through lifestyle changes: impact in the primary prevention of cardiovascular diseases.Heart. 2021; 107: 1429-1434
- Interventions that cause weight loss and the impact on cardiovascular risk factors: a systematic review and meta-analysis.Obes. Rev. 2016; 17: 1001-1011
- The association between weight loss and increased longevityA review of the evidence.Ann Intern Med. 1993; 119: 731-736
- Body weight and longevityA reassessment.JAMA. 1987; 257: 353-358
- Dose-response relationships between body composition indices and all-cause mortality in older Japanese adults.J Am Med Dir Assoc. 2020; 21 (e4): 726-733
- Metabolic health status and the obesity paradox in older adults.J. Nutr. Gerontol. Geriatr. 2016; 35: 161-176
- SANRA-a scale for the quality assessment of narrative review articles.Res. Integr. Peer Rev. 2019; 4: 5
- Writing narrative literature reviews for peer-reviewed journals: secrets of the trade.J Chiropr Med. 2006; 5: 101-117
- Body mass index, weight loss, and mortality in community-dwelling older adults.J. Gerontol. A Biol. Sci. Med. Sci. 2007; 62: 1389-1392
- Attribution of causes of weight loss and weight gain to 3-year mortality in older adults: results from the longitudinal aging study Amsterdam.J. Gerontol. A Biol. Sci. Med. Sci. 2014; 69: 1236-1243
- Prospective study of intentionality of weight loss and mortality in older women: the Iowa Women's Health Study.Am. J. Epidemiol. 1999; 149: 504-514
- Body mass index and short-term weight change in relation to mortality in dutch women after age 50 y.Am. J. Clin. Nutr. 2004; 80: 231-236
- Reasons for intentional weight loss, unintentional weight loss, and mortality in older men.Arch. Intern. Med. 2005; 165: 1035-1040
- Increased frequency of intentional weight loss associated with reduced mortality: a prospective cohort analysis.BMC Med. 2020; 18: 248
- Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40–64 years.Am. J. Epidemiol. 1995; 141: 1128-1141
- The relationship between weight loss and all-cause mortality in older men and women with and without diabetes mellitus: the Rancho Bernardo study.J. Am. Geriatr. Soc. 2002; 50: 1810-1815
- Intention to lose weight, weight changes, and 18-y mortality in overweight individuals without co-morbidities.PLoS Med. 2005; 2e171
- Weight cycling and mortality among middle-aged or older women.Arch. Intern. Med. 2009; 169: 881-886
- Prospective study of intentional weight loss and mortality in overweight white men aged 40–64 years.Am. J. Epidemiol. 1999; 149: 491-503
- The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial.Am. J. Clin. Nutr. 2011; 94: 839-846
- Intentional weight loss and longevity in overweight patients with type 2 diabetes: a population-based cohort study.PloS one. 2016; 11e0146889
- Weight loss causes increased mortality: cons.Obes. Rev. 2003; 4: 9-16
- Weight loss causes increased mortality: pros.Obes. Rev. 2003; 4: 3-7
Article info
Publication history
Published online: August 03, 2022
Accepted:
July 27,
2022
Received in revised form:
July 22,
2022
Received:
May 24,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.