Highlights
- •Among Chinese older adults, plasma superoxide dismutase activity was associated with disability in activities of daily living, as well as in standing up from a chair and in picking up a book from the floor.
- •We did not observe statistically significant age and sex differences regarding the associations of plasma superoxide dismutase activity with physical functioning.
- •The plasma superoxide dismutase activity has the potential to serve as a biomarker of physical functioning.
Abstract
Background
This study aimed to examine the associations of plasma superoxide dismutase (SOD)
activity, an indicator of oxidative stress, with disability in activities of daily
living (ADL) and objective physical functioning among Chinese older adults.
Methods
We used cross-sectional data of 2223 older adults (≥65 years, including 1505 adults≥80
years) from the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity
Survey (CLHLS) and the 2012 biomarker sub-study. Plasma SOD activity was assessed
by the T-SOD assay kit based on the hydroxylamine method. Outcomes included ADL disability
and disability in three objective physical tasks (standing up from a chair, picking
up a book from the floor, and turning around 360°). Logistic regression models were
used to examine the associations of plasma SOD activity with outcomes.
Results
After controlling for age and sex, compared with participants in the lowest quartile
group of SOD activity, those in the highest quartile group had 31% lower odds of ADL
disability (odds ratio [OR]: 0.69; 95%CI: 0.48, 0.98); 60% lower odds of disability
in standing up from a chair (OR: 0.40; 95%CI: 0.25, 0.63); and 57% lower odds of disability
in picking up a book from a floor (OR: 0.43; 95%CI: 0.28, 0.65). The results did not
change substantially after controlling for additional covariates. We did not observe
statistically significant age and sex differences.
Conclusions
Overall, plasma SOD activity was associated with subjectively and objectively measured
disability in Chinese older adults, highlighting the potential of SOD activity to
serve as a biomarker of physical functioning.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to MaturitasAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Rethinking Disability.BMC Med. 2018; 16 (Doi): 14https://doi.org/10.1186/s12916-017-1002-6
- Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.J. Gerontol. A Biol. Sci. Med. Sci. 2004; 59 (Doi): 255-263https://doi.org/10.1093/gerona/59.3.m255
- Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study.Lancet Public Health. 2020; 5 (Doi): e42-e50https://doi.org/10.1016/s2468-2667(19)30226-9
- Trajectories of disability in the last year of life.N. Engl. J. Med. 2010; 362 (Doi): 1173-1180https://doi.org/10.1056/NEJMoa0909087
- Short-term disability fluctuations in late life.J. Gerontol. B Psychol. Sci. Soc. Sci. 2019; 74 (Doi): e135-ee40https://doi.org/10.1093/geronb/gbz089
- Markers of oxidative stress in erythrocytes and plasma during aging in humans.Oxid. Med. Cell Longev. 2010; 3 (Doi): 2-12https://doi.org/10.4161/oxim.3.1.10476
- Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?.Br. J. Pharmacol. 2004; 142 (Doi): 231-255https://doi.org/10.1038/sj.bjp.0705776
- First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid.Alexandria J. Med. 2019; 54 (Doi): 287-293https://doi.org/10.1016/j.ajme.2017.09.001
- A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.Geroscience. 2017; 39 (Doi): 187-198https://doi.org/10.1007/s11357-017-9975-9
- Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.Free Radic. Biol. Med. 2019; 132 (Doi): 19-23https://doi.org/10.1016/j.freeradbiomed.2018.06.032
- Biological markers of oxidative stress: applications to cardiovascular research and practice.Redox. Biol. 2013; 1 (Doi): 483-491https://doi.org/10.1016/j.redox.2013.07.006
- Superoxide dismutase activity and risk of cognitive decline in older adults: findings from the Chinese longitudinal healthy longevity survey.Exp. Gerontol. 2019; 118 (Doi): 72-77https://doi.org/10.1016/j.exger.2019.01.010
- Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment.Aging Dis. 2019; 10 (Doi): 834-846https://doi.org/10.14336/ad.2019.0304
- Cognition impairment in schizophrenia patients with tardive dyskinesia: association with plasma superoxide dismutase activity.Schizophr. Res. 2014; 152 (Doi): 210-216https://doi.org/10.1016/j.schres.2013.11.010
- Relationship between decreased serum superoxide dismutase activity and metabolic syndrome: synergistic mediating role of insulin resistance and β-cell dysfunction.Oxid. Med. Cell Longev. 2020; 2020 (Doi)5384909https://doi.org/10.1155/2020/5384909
- Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.BMC Geriatr. 2019; 19 (Doi): 104https://doi.org/10.1186/s12877-019-1109-z
- Healthy longevity in China : demographic, socioeconomic, and psychological dimensions.Springer Ebooks. 2008; 63 (Doi): 312-313https://doi.org/10.1007/978-1-4020-6752-5
- Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function.JAMA. 1963; 185 (Doi): 914-919https://doi.org/10.1001/jama.1963.03060120024016
- Serum 25-hydroxyvitamin D in relation to disability in activities of daily living, mobility, and objective physical functioning among Chinese older adults.Exp. Gerontol. 2021; 148 (Doi)111290https://doi.org/10.1016/j.exger.2021.111290
- Effect of new disability subtype on 3-year mortality in Chinese older adults.J. Am. Geriatr. Soc. 2010; 58 (Doi): 1952-1958https://doi.org/10.1111/j.1532-5415.2010.03013.x
- Contributions of obesity and cigarette smoking to incident disability: a longitudinal analysis.Prev. Med. 2020; 141 (Doi)106226https://doi.org/10.1016/j.ypmed.2020.106226
- The role of vitamin K in humans: implication in aging and age-associated diseases.Antioxidants (Basel). 2021; 10 (Doi)https://doi.org/10.3390/antiox10040566
- Frailty in older adults: evidence for a phenotype.J. Gerontol. A Biol. Sci. Med. Sci. 2001; 56 (Doi): M146-M156https://doi.org/10.1093/gerona/56.3.m146
- Increased oxidative stress in patients with severe disability: association with nutrition.Pediatr. Int. 2016; 58 (Doi): 1183-1187https://doi.org/10.1111/ped.12977
- Oxidative stress and severe walking disability among older women.Am. J. Med. 2007; 120 (Doi): 1084-1089https://doi.org/10.1016/j.amjmed.2007.07.028
- Frailty as a phenotypic manifestation of underlying oxidative stress.Free Radic. Biol Med. 2020; 149 (Doi): 72-77https://doi.org/10.1016/j.freeradbiomed.2019.08.011
- Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?.J. Appl. Physiol. (1985). 2016; 121 (Doi): 1047-1052https://doi.org/10.1152/japplphysiol.00321.2016
- Sex differences in lifespan.Cell Metab. 2016; 23 (Doi): 1022-1033https://doi.org/10.1016/j.cmet.2016.05.019
- Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action.Pharm. Res. 2013; 30 (Doi): 2718-2728https://doi.org/10.1007/s11095-013-1113-5
- Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory.Behav. Brain Res. 2009; 200 (Doi): 15-21https://doi.org/10.1016/j.bbr.2008.12.038
- Enhanced recovery of phenolic and tocopherolic compounds from Walnut (Juglans Regia L.) male flowers based on process optimization of ultrasonic assisted-extraction: phytochemical profile and biological activities.Antioxidants (Basel). 2021; 10 (Doi)https://doi.org/10.3390/antiox10040607
Article info
Publication history
Published online: February 10, 2022
Accepted:
January 19,
2022
Received in revised form:
January 3,
2022
Received:
June 26,
2021
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
