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Plasma superoxide dismutase activity in relation to disability in activities of daily living and objective physical functioning among Chinese older adults

  • Author Footnotes
    1 These authors contributed equally to this work.
    Xueqin Li
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Big Data in Health Science and Center for Clinical Big Data and Analytics, Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Xingqi Cao
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Big Data in Health Science and Center for Clinical Big Data and Analytics, Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.
    Zhimin Ying
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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  • Guangtao Yang
    Affiliations
    School of Laboratory Medicine and School of Life Sciences, Wenzhou Medical University, Wenzhou, China
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  • Emiel O Hoogendijk
    Affiliations
    Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam UMC-location VU University Medical Center, Amsterdam, the Netherlands
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  • Zuyun Liu
    Correspondence
    Corresponding author at: School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China.
    Affiliations
    Department of Big Data in Health Science and Center for Clinical Big Data and Analytics, Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Highlights

      • Among Chinese older adults, plasma superoxide dismutase activity was associated with disability in activities of daily living, as well as in standing up from a chair and in picking up a book from the floor.
      • We did not observe statistically significant age and sex differences regarding the associations of plasma superoxide dismutase activity with physical functioning.
      • The plasma superoxide dismutase activity has the potential to serve as a biomarker of physical functioning.

      Abstract

      Background

      This study aimed to examine the associations of plasma superoxide dismutase (SOD) activity, an indicator of oxidative stress, with disability in activities of daily living (ADL) and objective physical functioning among Chinese older adults.

      Methods

      We used cross-sectional data of 2223 older adults (≥65 years, including 1505 adults≥80 years) from the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Plasma SOD activity was assessed by the T-SOD assay kit based on the hydroxylamine method. Outcomes included ADL disability and disability in three objective physical tasks (standing up from a chair, picking up a book from the floor, and turning around 360°). Logistic regression models were used to examine the associations of plasma SOD activity with outcomes.

      Results

      After controlling for age and sex, compared with participants in the lowest quartile group of SOD activity, those in the highest quartile group had 31% lower odds of ADL disability (odds ratio [OR]: 0.69; 95%CI: 0.48, 0.98); 60% lower odds of disability in standing up from a chair (OR: 0.40; 95%CI: 0.25, 0.63); and 57% lower odds of disability in picking up a book from a floor (OR: 0.43; 95%CI: 0.28, 0.65). The results did not change substantially after controlling for additional covariates. We did not observe statistically significant age and sex differences.

      Conclusions

      Overall, plasma SOD activity was associated with subjectively and objectively measured disability in Chinese older adults, highlighting the potential of SOD activity to serve as a biomarker of physical functioning.

      Keywords

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