Rapid Communication| Volume 158, P37-39, April 2022

Selective serotonin reuptake inhibitors and fractures in older nursing home residents: Data from the INCUR study


      • Depression and the use of selective serotonin reuptake inhibitors (SSRIs) are associated with osteoporosis.
      • SSRIs can increase fracture risk.
      • SSRIs are associated with fractures in nursing home residents.
      • A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.


      Depression and selective serotonin reuptake inhibitors (SSRI) reduce bone mass and increase fracture risk. We analyzed the association between SSRI use and fractures development in nursing homes residents during a one-year prospective observational study. Sixty-four of the 800 participants developed a fracture during the one-year follow-up. Individuals who developed fractures used SSRIs more often than residents who did not (40.6% vs 28.7%, p =0.045). SSRIs were associated with fractures (adjusted OR 1.76, 95% CI 1.04 – 2.98, p = 0.036). A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.


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