- •Depression and the use of selective serotonin reuptake inhibitors (SSRIs) are associated with osteoporosis.
- •SSRIs can increase fracture risk.
- •SSRIs are associated with fractures in nursing home residents.
- •A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.
Depression and selective serotonin reuptake inhibitors (SSRI) reduce bone mass and increase fracture risk. We analyzed the association between SSRI use and fractures development in nursing homes residents during a one-year prospective observational study. Sixty-four of the 800 participants developed a fracture during the one-year follow-up. Individuals who developed fractures used SSRIs more often than residents who did not (40.6% vs 28.7%, p =0.045). SSRIs were associated with fractures (adjusted OR 1.76, 95% CI 1.04 – 2.98, p = 0.036). A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.
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Published online: November 20, 2021
Accepted: November 17, 2021
Received in revised form: November 11, 2021
Received: August 24, 2021
© 2021 Elsevier B.V. All rights reserved.