Highlights
- •Depression and the use of selective serotonin reuptake inhibitors (SSRIs) are associated with osteoporosis.
- •SSRIs can increase fracture risk.
- •SSRIs are associated with fractures in nursing home residents.
- •A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.
Abstract
Depression and selective serotonin reuptake inhibitors (SSRI) reduce bone mass and
increase fracture risk. We analyzed the association between SSRI use and fractures
development in nursing homes residents during a one-year prospective observational
study. Sixty-four of the 800 participants developed a fracture during the one-year
follow-up. Individuals who developed fractures used SSRIs more often than residents
who did not (40.6% vs 28.7%, p =0.045). SSRIs were associated with fractures (adjusted
OR 1.76, 95% CI 1.04 – 2.98, p = 0.036). A regular medication review should be performed
to reduce inappropriate prescriptions and related adverse consequences.
Keywords
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References
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Article info
Publication history
Published online: November 20, 2021
Accepted:
November 17,
2021
Received in revised form:
November 11,
2021
Received:
August 24,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
