Highlights
- •Muscular strength plays an important role in the prevention of hypertension.
- •High weight-adjusted handgrip strength was related to low risk of hypertension in males and females.
- •High weight-adjusted handgrip strength may contribute to decreasing the risk of hypertension.
Abstract
Objectives
The independent role of muscular strength in the prevention of chronic disease is
increasingly being recognized. However, no cohort study has assessed the relationship
between handgrip strength and the incidence of hypertension among the middle-aged
and older population. The aim of this prospective cohort study was to investigate
whether handgrip strength is related to incident hypertension among people aged 40
years and over.
Study design
This prospective cohort study (n = 8,480) was performed between 2013 and 2019 as part of the Tianjin Chronic Low-grade
Systemic Inflammation and Health (TCLSIH) Cohort Study, Tianjin, China.
Main outcome measures
Participants without baseline hypertension were followed up for ~6 years (median 4.0
years). Hypertension was defined according to the JNC7 criteria. Handgrip strength
was measured using a hydraulic handheld dynamometer. Adjusted Cox proportional hazards
regression models were used to assess the relationships between weight-adjusted handgrip
strength and the risk of incident hypertension.
Results
The incidence rate of hypertension per 1000 person-years was 70. The fully adjusted
hazards ratios (95% confidence interval) of the incidence of hypertension for increasing
quartiles of weight-adjusted handgrip strength were: 1.00(reference), 0.84 (0.75–0.95),
0.78 (0.69–0.88), and 0.66 (0.58–0.75) (P for trend<0.0001). Moreover, the adjusted hazards ratio (95% confidence interval)
of incident hypertension for per unit increase in weight-adjusted handgrip strength
was 0.17 (0.10–0.27) (P<0.0001). Similar results were observed in males and females.
Conclusions
The present cohort study is the first to find that high weight-adjusted handgrip strength,
but not absolute handgrip strength, is significantly and independently related to
low risk of incident hypertension among the middle-aged and older population.
Keywords
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Article info
Publication history
Published online: June 10, 2021
Accepted:
June 8,
2021
Received in revised form:
April 15,
2021
Received:
January 7,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
