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Handgrip strength as a predictor of incident hypertension in the middle-aged and older population: The TCLSIH cohort study

  • Yeqing Gu
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
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  • Jun Dong
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Ge Meng
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China

    Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China
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  • Qing Zhang
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Li Liu
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Hongmei Wu
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Shunming Zhang
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Yawen Wang
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Tingjing Zhang
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Xuena Wang
    Affiliations
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
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  • Shaomei Sun
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Xing Wang
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Qiyu Jia
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Kun Song
    Affiliations
    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
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  • Qiang Liu
    Correspondence
    Corresponding authors: Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, 238 Baidi Road, Nankai District, Tianjin 300192, China.
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
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  • Kaijun Niu
    Correspondence
    Corresponding authors: Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, 238 Baidi Road, Nankai District, Tianjin 300192, China.
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China

    Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China

    Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China

    Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China
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      Highlights

      • Muscular strength plays an important role in the prevention of hypertension.
      • High weight-adjusted handgrip strength was related to low risk of hypertension in males and females.
      • High weight-adjusted handgrip strength may contribute to decreasing the risk of hypertension.

      Abstract

      Objectives

      The independent role of muscular strength in the prevention of chronic disease is increasingly being recognized. However, no cohort study has assessed the relationship between handgrip strength and the incidence of hypertension among the middle-aged and older population. The aim of this prospective cohort study was to investigate whether handgrip strength is related to incident hypertension among people aged 40 years and over.

      Study design

      This prospective cohort study (n = 8,480) was performed between 2013 and 2019 as part of the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study, Tianjin, China.

      Main outcome measures

      Participants without baseline hypertension were followed up for ~6 years (median 4.0 years). Hypertension was defined according to the JNC7 criteria. Handgrip strength was measured using a hydraulic handheld dynamometer. Adjusted Cox proportional hazards regression models were used to assess the relationships between weight-adjusted handgrip strength and the risk of incident hypertension.

      Results

      The incidence rate of hypertension per 1000 person-years was 70. The fully adjusted hazards ratios (95% confidence interval) of the incidence of hypertension for increasing quartiles of weight-adjusted handgrip strength were: 1.00(reference), 0.84 (0.75–0.95), 0.78 (0.69–0.88), and 0.66 (0.58–0.75) (P for trend<0.0001). Moreover, the adjusted hazards ratio (95% confidence interval) of incident hypertension for per unit increase in weight-adjusted handgrip strength was 0.17 (0.10–0.27) (P<0.0001). Similar results were observed in males and females.

      Conclusions

      The present cohort study is the first to find that high weight-adjusted handgrip strength, but not absolute handgrip strength, is significantly and independently related to low risk of incident hypertension among the middle-aged and older population.

      Keywords

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