Highlights
- •In this study, we show that HOTAIR polymorphisms rs4759314, rs920778, rs1899663, and rs7958904 are associated with primary ovarian insufficiency.
- •The GT genotype of rs1899663 of HOTAIR polymorphisms was associated with a decreased risk of primary ovarian insufficiency compared with other genotypes at that locus.
- •The combination of the AA genotype of rs4759314 and the GC genotype of rs7958904 was associated with a decreased risk of primary ovarian insufficiency.
- •The GG genotype of rs1899663 and the GC genotype of rs7958904 were associated with an increased risk of primary ovarian insufficiency compared with the wild-type homozygous genotypes.
- •Our results suggest that the HOTAIR polymorphisms rs4759314, rs920778, rs1899663, and rs7958904 are involved in primary ovarian insufficiency.
Abstract
Background
We investigated the association between the Hox transcript antisense RNA (HOTAIR)
polymorphisms rs4759314, rs920778, rs1899663, and rs7958904 and primary ovarian insufficiency
(POI) in Korean women.
Methods
We conducted a case-control study of 134 Korean women with POI and 383 control individuals
with at least one live birth and no history of pregnancy loss.
Results
The GT genotype of rs1899663 was associated with a decreased risk of POI compared
with other genotypes at that locus. In addition, compared with the wild-type homozygous
genotypes, the combination of the AA genotype of rs4759314 and the GC genotype of
rs7958904 was associated with a decreased risk of POI (P < 0.05), whereas the combination
of the GG genotype of rs1899663 and the GC genotype of rs7958904 was associated with
an increased risk of POI (P = 0.003). Haplotype analysis revealed that certain haplotypes
involving some or all of the polymorphisms were associated with a decreased risk of
POI, whereas other haplotypes were associated with an increased risk of POI. Serum
levels of luteinizing hormone, follicle-stimulating hormone, and estradiol differed
between patients with POI and control individuals (P < 0.05).
Conclusions
Our results suggest that the HOTAIR polymorphisms rs4759314, rs920778, rs1899663,
and rs7958904 are involved in POI.
Keywords
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Article info
Publication history
Published online: November 04, 2020
Accepted:
October 30,
2020
Received in revised form:
August 21,
2020
Received:
November 25,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.