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Editorial| Volume 135, P80-81, May 2020

Sex and time: A new complexity in research

  • Walter A. Rocca
    Correspondence
    Corresponding author at: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    Affiliations
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Search for articles by this author
      Throughout the course of history, sex as a biological variable has interacted with social and cultural practices related to gender over the life course of people. These age-dependent interactions and calendar-time-dependent interactions contribute to health and disease, especially in the later part of life, during aging [
      • Rocca W.A.
      • Mielke M.M.
      • Vemuri P.
      • Miller V.M.
      Sex and gender differences in the causes of dementia: a narrative review.
      ]. These interactions may be particularly complex and remain partly unknown for transgender persons who undergo gender-affirming treatment [
      • T’Sjoen G.
      • Arcelus J.
      • Gooren L.
      • Klink D.T.
      • Tangpricha V.
      Endocrinology of transgender medicine.
      ,
      • Hembree W.C.
      • Cohen-Kettenis P.T.
      • Gooren L.
      • Hannema S.E.
      • Meyer W.J.
      • Murad M.H.
      • Rosenthal S.M.
      • Safer J.D.
      • Tangpricha V.
      • T’Sjoen G.G.
      Endocrine treatment of gender-dysphoric/gender-incongruent persons: an endocrine society clinical practice guideline.
      ].
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      References

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        Sex and gender differences in the causes of dementia: a narrative review.
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        Endocr. Rev. 2019; 40: 97-117
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        Endocrine treatment of gender-dysphoric/gender-incongruent persons: an endocrine society clinical practice guideline.
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