Highlights
- •The prevalence of osteoporosis and low muscle mass was 8.9 % and 9.9 %, respectively.
- •Low muscle mass was significantly associated with osteoporosis in both men and women.
- •The significant association between low muscle mass and osteoporosis remained in all age groups except for men 50–64 years.
Abstract
Objectives
To assess the association between low muscle mass and osteoporosis in the Korean general
population.
Methods
We analyzed 14,429 participants (6,261 men and 8,168 women) from the 2009–2011 Korean
National Health and Nutrition Examination Survey (KNHANES) aged 20 years or more.
Main outcome measure
The association of low muscle mass with osteoporosis was investigated using multivariate
logistic regression models that included age, marital status, residence, current smoking,
monthly drinking, physical activities, strength exercise, comorbidity, and the use
of dietary supplements, and in women postmenopausal status and experience of pregnancy.
Results
After adjusting for covariates, low muscle mass was significantly associated with
osteoporosis in the lumbar spine and femoral neck in both men (lumbar spine: OR 1.73,
95 % CI 1.08–2.76; femoral neck: OR 3.39, 95 % CI 1.69–6.80) and women (lumbar spine:
OR 1.52, 95 % CI 1.17–1.97; femoral neck: OR 2.09, 95 % CI 1.56–2.80). Also, the association
between low muscle mass and osteoporosis was significant in men and women in every
age group except for men aged 50–64 years.
Conclusion
Low muscle mass was significantly associated with osteoporosis in both men and women
for all age groups, except for men aged 50–64 years.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to MaturitasAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Osteoporosis: the evolution of a diagnosis.J. Intern. Med. 2015; 277: 650-661https://doi.org/10.1111/joim.12369
- Epidemiology, etiology, and diagnosis of osteoporosis.Am. J. Obstet. Gynecol. 2006; 194: S3-S11
- Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women.JAMA. 2009; 301: 513-521https://doi.org/10.1001/jama.2009.50
- Operational definitions of sarcopenia and their associations with 5-year changes in falls risk in community-dwelling middle-aged and older adults.Osteoporos. Int. 2014; 25: 187-193
- Association between sarcopenia and higher-level functional capacity in daily living in community-dwelling elderly subjects in Japan.Arch. Gerontol. Geriatr. 2012; 55: e9-13
- Linkage between muscle and bone: common catabolic signals resulting in osteoporosis and sarcopenia.Curr. Opin. Clin. Nutr. Metab. Care. 2013; 16: 272-277https://doi.org/10.1097/MCO.0b013e32835fe6a5
- Osteoporosis and sarcopenia: two diseases or one?.Curr. Opin. Clin. Nutr. Metab. Care. 2016; 19: 31-36https://doi.org/10.1097/MCO.0000000000000230
- Relationship between postmenopausal osteoporosis and the components of clinical sarcopenia.Maturitas. 2013; 75: 175-180https://doi.org/10.1016/j.maturitas.2013.03.016
- Association between sarcopenic obesity and bone mineral density in middle-aged and elderly Korean.Ann. Nutr. Metab. 2016; 68: 77-84https://doi.org/10.1159/000442004
- Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density.Osteoporos. Int. 2006; 17: 61-67https://doi.org/10.1007/s00198-005-1900-x
- Body fat and physical activity modulate the association between sarcopenia and osteoporosis in elderly Korean women.J. Sports Sci. Med. 2016; 15: 477-482
- Relationship of sarcopenia and body composition with osteoporosis.Osteoporos. Int. 2016; 27: 473-482https://doi.org/10.1007/s00198-015-3241-8
- The association between the low muscle mass and osteoporosis in elderly Korean people.J. Korean Med. Sci. 2014; 29: 995-1000https://doi.org/10.3346/jkms.2014.29.7.995
- FiAT intervention group, Osteosarcopenia is more than sarcopenia and osteopenia alone.Aging Clin. Exp. Res. 2016; 28: 895-899https://doi.org/10.1007/s40520-015-0494-1
- High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea.Eur. J. Pediatr. 2012; 171: 1475-1480https://doi.org/10.1007/s00431-012-1746-0
- Data resource profile: the Korea national health and nutrition examination survey (KNHANES).Int. J. Epidemiol. 2014; 43: 69-77https://doi.org/10.1093/ije/dyt228
- The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates.J. Gerontol. A Biol. Sci. Med. Sci. 2014; 69: 547-558https://doi.org/10.1093/gerona/glu010
- Epidemiology of sarcopenia among the elderly in New Mexico.Am. J. Epidemiol. 1998; 147: 755-763https://doi.org/10.1093/oxfordjournals.aje.a009520
- The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning.Obesity. 2012; 20: 2101-2106https://doi.org/10.1038/oby.2012.20
- Factors affecting sarcopenia in Korean adults by age groups.Osong Public Health Res. Perspect. 2017; 8: 169-178
- Prevalence of sarcopenia and sarcopenic obesity in the Korean population based on the Fourth Korean National Health and Nutritional Examination Surveys.J. Gerontol. A Biol. Sci. Med. Sci. 2012; 67: 1107-1113https://doi.org/10.1093/gerona/gls071
- Sarcopenia in Asia: consensus report of the Asian working group for sarcopenia.J. Am. Med. Dir. Assoc. 2014; 15: 95-101https://doi.org/10.1016/j.jamda.2013.11.025
- Prevalence of sarcopenia in the Korean woman based on the Korean national health and nutritional examination surveys.J. Bone Metab. 2016; 23: 23-26https://doi.org/10.11005/jbm.2016.23.1.23
- The ageing muscle.Clin. Physiol. 1983; 3: 209-218
- Prevalence of sarcopenia and associated factors among Thai population.J. Bone Miner. Metab. 2013; 31: 346-350https://doi.org/10.1007/s00774-013-0422-4
- Bone’s mechanostat: a 2003 update.Anat. Rec. A Discov. Mol. Cell Evol. Biol. 2003; 275: 1081-1101https://doi.org/10.1002/ar.a.10119
- Interactions between muscle tissues and bone metabolism.J. Cell. Biochem. 2015; 116: 687-695https://doi.org/10.1002/jcb.25040
- Clinical outcomes of impaired muscle and bone interactions.Clinic. Rev. Bone Miner. Metab. 2014; 12: 86-92https://doi.org/10.1007/s12018-014-9164-7
- Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise.Cell Metab. 2016; 23: 1078-1092https://doi.org/10.1016/j.cmet.2016.05.004
- Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF.PLoS One. 2012; 7e37512https://doi.org/10.1371/journal.pone.0037512
- Muscle and bone, two interconnected tissues.Ageing Res. Rev. 2015; 21: 55-70https://doi.org/10.1016/j.arr.2015.03.002
- Osteosarcopenia: where bone, muscle, and fat collide.Osteoporos. Int. 2017; 28: 2781-2790
- Beyond FRAX: it’s time to consider “sarco-osteopenia”.J. Clin. Densitom. 2009; 12: 413-416
- Osteosarcopenia: a new geriatric syndrome.Aust. Fam. Phys. 2017; 46: 849-853
- Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi study.Bone. 2008; 42: 271-277https://doi.org/10.1016/j.bone.2007.09.056
- The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu study.J. Bone Miner. Metab. 2016; 34: 555-563https://doi.org/10.1007/s00774-015-0696-9
- Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People.Age Ageing. 2010; 39: 412-423
Article Info
Publication History
Published online: January 07, 2020
Accepted:
January 7,
2020
Received in revised form:
December 9,
2019
Received:
October 16,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
