LBP01| Volume 128, P96, October 2019

Normalization of ovarian reserve surrogates in a women diagnosed with psoriasis treated with TNF-alpha antagonist. A case report

      Introduction: Psoriasis and psoriatic arthritis (PsA) are chronic inflammatory diseases of unclear etiology. There is evidence, that genetic, immunologic, and environmental factors contribute to its pathology. Autoimmune oophoritis has been proposed as one of the possible etiologies of diminished ovarian reserve. Pro-inflammatory cytokine - tumor necrosis factor alpha (TNFα) is implicated in the pathogenesis of oophoritis and psoriasis. Certolizumab is an anti-TNFα monoclonal antibody studied now in the treatment of psoriasis. Here we present a case of a patient diagnosed with psoriasis, PsA and diminished ovarian reserve, in which we observed normalization of ovarian reserve surrogates after treatment with certolizumab. To our knowledge, it is a first such a case report in the literature.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Maturitas
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect