In 13–50%, Ductal Carcinoma In Situ (DCIS) progresses to an Invasive Ductal Carcinoma
(IDC). As the individual progression risk from DCIS to IDC cannot be estimated based
on clinical parameters or biomarkers, all patients with DCIS are medically treated
equally. However, the role of tumor microenvironment and especially of tumor-associated
fibroblasts (TAFs) appears to be critical for progression from DCIS to IDC. Based
on previous work by Sameni et al. (2012), the aim of this study was to establish a
3D co-culture of primary fibroblasts and DCIS cells in vitro as a model for further
investigations of TAFs’ role in breast cancer progression.
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Publication history
Published online: August 06, 2019
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© 2019 Published by Elsevier Inc.
