Highlights
- •There is insufficient evidence on the relationship between dietary phytochemicals and osteoarthritis.
- •Dietary polyphenols intake from foods may slow the progression of osteoarthritis.
- •High-quality epidemiological studies and controlled trials are therefore required.
Abstract
Osteoarthritis is the most prevalent chronic inflammatory joint disease affecting
mobility in humans, as well as in companion and captive animals. Understanding the
effect of dietary phytochemical intake from foods on osteoarthritis and its long-term
outcomes may inform public health strategies for osteoarthritis prevention and management,
reducing healthcare costs globally. The aim of this systematic review was to examine
the effects of dietary phytochemical intake from foods on osteoarthritis in adult
populations. A literature search was performed using Scopus, Web of Science, MEDLINE,
PubMed and the Cochrane Library for human studies to identify randomised controlled
trials (RCTs) and observational studies focused on osteoarthritis up to May 2018.
From 5879 articles, five RCTs and four cross-sectional studies were identified. Dietary
carotenoids were examined in the observational studies, while dietary intakes of polyphenols
from foods were assessed in the RCTs. Dietary polyphenol intake from foods (e.g.,
freeze-dried strawberries and tart cherry juice) may slow the progression of osteoarthritis
via decreased inflammation and reduced cartilage degradation. However, there were
relatively few studies and a lack of uniformity in the biomarkers used and the measurements
of pain, quality of life and physical activity relating to osteoarthritis. The heterogeneity
among the studies suggests that there is insufficient evidence related to phytochemical
intake from foods. High-quality epidemiological studies and controlled trials are
therefore required. Nevertheless, exploring dietary phytochemical intake from foods
may complement current dietary strategies for the management of osteoarthritis and
help in the formulation of more economical and manageable strategies for osteoarthritis.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to MaturitasAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Chronic Rheumatic Conditions.(09 Sep 2018]; Available from:)2018
- Health economics in the field of osteoarthritis: an expert’s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).Semin. Arthritis Rheum. 2013; 43: 303-313
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.Lancet. 2017; 390: 1211-1259
- Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.Lancet. 2015; 386: 743-800
- Knee osteoarthritis has doubled in prevalence since the mid-20th century.Proc. Natl. Acad. Sci. 2017; 114: 9332-9336
- Aging and osteoarthritis.Curr. Opin. Rheumatol. 2011; 23: 492-496
- Tackling obesity in knee osteoarthritis.Nat. Rev. Rheumatol. 2012; 9: 225
- Joint instability and osteoarthritis.Clin. Med. Insights Arthritis Musculoskelet. Disord. 2015; 8 (CMAMD.S22147)
- The incidence and natural history of knee osteoarthritis in the elderly, the Framingham osteoarthritis study.Arthritis Rheum. 1995; 38: 1500-1505
- Risk factors for osteoarthritis: genetics11Supported by Procter & Gamble Pharmaceuticals, Mason, OH.Osteoarthr. Cartil. 2004; 12: 39-44
- Metabolic syndrome meets osteoarthritis.Nat. Rev. Rheumatol. 2012; 8: 729
- Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis.RMD Open. 2015; 1
- Osteoarthritis.Lancet. 2015; 386: 376-387
- The role of metabolism in the pathogenesis of osteoarthritis.Nat. Rev. Rheumatol. 2017; 13: 302
- Is radiology a determinant of pain, stiffness, and functional disability in knee osteoarthritis? A cross-sectional study.J. Orthop. Sci. 2011; 16: 719-725
- Biomechanical factors in osteoarthritis.Best Pract. Res. Clin. Rheumatol. 2011; 25: 815-823
- Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).Osteoarthr. Cartil. 2013; 21: 16-21
- Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.Nutr. J. 2016; 15: 1
- Natural products for promoting joint health and managing osteoarthritis.Curr. Rheumatol. Rep. 2018; 20: 72
- Dietary polyphenols and mechanisms of osteoarthritis.J. Nutr. Biochem. 2012; 23: 1367-1377
- Which supplements can I recommend to my osteoarthritis patients?.Rheumatology. 2018; 57: iv75-iv87
- Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.Br. J. Sports Med. 2018; 52: 167-175
- Dietary phytochemical intake from foods and health outcomes: a systematic review protocol and preliminary scoping.BMJ Open. 2017; 7
- Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011].The Cochrane Collaboration, 2011
- ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions.BMJ. 2016; : 355
- Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?.Arthritis Rheum. 1996; 39: 648-656
- Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study.Arthritis Res. Ther. 2007; 9
- Association between dietary intake of antioxidants and prevalence of femoral head cartilage defects and bone marrow lesions in community-based adults.J. Rheumatol. 2016; 43: 1885-1890
- Relationship between total fruit and vegetable intake and self-reported knee pain in older adults.J. Nutr. Health Aging. 2017; 21: 750-758
- Soy protein may alleviate osteoarthritis symptoms.Phytomedicine. 2004; 11: 567-575
- Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee.Osteoarthr. Cartil. 2013; 21: 1035-1041
- High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms.J. Med. Food. 2014; 17: 1361-1367
- The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis.J. Sci. Food Agric. 2016; 96: 4377-4381
- Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis.Nutrients. 2017; 9
- Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint.Arthritis Rheum. 2009; 60: 1722-1732
- Osteoarthritis.J. Cell. Physiol. 2007; 213: 626-634
- Sex hormones and structural changes in osteoarthritis: a systematic review.Maturitas. 2011; 69: 141-156
- Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis.Ann. Rheum. Dis. 2015; 74: 703-710
- Polyphenols: food sources and bioavailability.Am. J. Clin. Nutr. 2004; 79: 727-747
- Gut microbiota functions: metabolism of nutrients and other food components.Eur. J. Nutr. 2018; 57: 1-24
- Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.Biomed Res. Int. 2015; 2015: 18
- A systematic literature review of the effect of anthocyanins on gut microbiota populations.J. Hum. Nutr. Diet. 2018; 0
- Profiling of phenols in human fecal water after raspberry supplementation.J. Agric. Food Chem. 2010; 58: 10389-10395
- Bioavailability of phyto-oestrogens.Br. J. Nutr. 2003; 89: S45-S58
- A systematic review of food composition tools used for determining dietary polyphenol intake in estimated intake studies.Food Chem. 2018; 238: 146-152
- Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis.Ann. Rheum. Dis. 2007; 66: 433-439
- What is the evidence for a role for diet and nutrition in osteoarthritis?.Rheumatology. 2018; 57: iv61-iv74
- Increasing low-energy-dense foods and decreasing high-energy-dense foods differently influence weight loss trial outcomes.Int. J. Obes. 2017; 42: 479
Article info
Publication history
Published online: January 11, 2019
Accepted:
January 10,
2019
Received:
January 7,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
