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Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study

  • Walter A. Rocca
    Correspondence
    Corresponding author at: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States.
    Affiliations
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States

    Department of Neurology, Mayo Clinic, Rochester, MN, United States

    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States
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  • Liliana Gazzuola Rocca
    Affiliations
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States
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  • Carin Y. Smith
    Affiliations
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States
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  • Brandon R. Grossardt
    Affiliations
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States
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  • Stephanie S. Faubion
    Affiliations
    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States

    Women’s Health Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States
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  • Lynne T. Shuster
    Affiliations
    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States

    Women’s Health Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States
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  • Elizabeth A. Stewart
    Affiliations
    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States

    Department of Surgery, Mayo Clinic, Rochester, MN, United States

    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States
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  • Michelle M. Mielke
    Affiliations
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States

    Department of Neurology, Mayo Clinic, Rochester, MN, United States

    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States
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  • Kejal Kantarci
    Affiliations
    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States

    Department of Radiology, Mayo Clinic, Rochester, MN, United States
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  • Virginia M. Miller
    Affiliations
    Women’s Health Research Center, Mayo Clinic, Rochester, MN, United States

    Department of Surgery, Mayo Clinic, Rochester, MN, United States
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Published:September 14, 2018DOI:https://doi.org/10.1016/j.maturitas.2018.09.002

      Highlights

      • Infertility was more common in women who underwent bilateral oophorectomy than in controls.
      • Women who underwent bilateral oophorectomy weighed more and had a higher body mass index than controls.
      • Use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common in women who underwent bilateral oophorectomy than in controls, and they were older at menarche than controls.
      • A family history of cancer was more common in women who underwent bilateral oophorectomy.
      • Approximately 51% of women in this population-based surgical series were found to have healthy ovaries at pathological examination.

      Abstract

      Objectives

      We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population.

      Study design

      In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP http://www.rochesterproject.org) to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication. Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone bilateral oophorectomy as of the index date. We used case-control analyses to investigate several characteristics associated with bilateral oophorectomy. Odds ratios and their 95% confidence intervals were adjusted for race, education, and income.

      Results

      In the overall analyses, infertility was more common in women who underwent bilateral oophorectomy than in the controls, whereas use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common. The women who underwent bilateral oophorectomy weighed more than controls, had a higher body mass index and were younger at menarche. The associations were more pronounced for women who underwent the bilateral oophorectomy before age 46 years, and some associations were different for women with or without a benign ovarian indication. Reported family histories of uterine and other cancers were more common in women without a benign ovarian indication.

      Conclusions

      We identified a number of personal, reproductive, and familial characteristics that were associated with bilateral oophorectomy over a 20-year period. Our historical findings may help inform decision-making about oophorectomy in the future.

      Keywords

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