Highlights
- •Vertebral fractures (VF) are a hallmark of osteoporosis and important cause of morbidity and mortality.
- •Moderate/severe VF fractures were associated with trabecular volumetric bone density using HR-pQCT at tibia in older women.
- •Moderate/severe VF were associated with femoral neck areal bone mineral density in older men from community.
Abstract
Background
Many vertebral fractures (VF) occur in individuals classified by DXA as being at low
risk of fragility fractures. The aim of this study was to verify the association between
VF and peripheral bone microarchitecture and strength parameters (SP) using, in addition
to DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT) and
axial bone microarchitecture using the trabecular bone score (TBS).
Study design
Cross-sectional study of 276 community-dwelling subjects aged ≥65 years from the SPAH
study cohort.
Methods
Lateral DXA scans of the spine were analyzed to assess VF. HR-pQCT was performed at
the radius and tibia. TBS was determined using DXA.
Results
VF was observed in 42.6% of women and 28% of men. At the tibia, women with moderate/severe
VF had lower volumetric bone density (vBMD), trabecular number (Tb.N), and SP, and
higher trabecular separation (Tb.Sp); and men with VF had lower Tb.N and SP, and higher
Tb.Sp. At the radius, women with moderate/severe VF had lower vBMD, trabecular and
cortical thickness and SP; and men with VF had lower trabecular vBMD and SP. No associations
between TBS and VF were observed in either gender. Logistic regression analysis revealed
that trabecular vBMD at the tibia in women (OR:0.980, 95%CI:0.963–0.997, p = 0.022)
and femoral neck aBMD in men (OR:0.445, 95%CI:0.212–0.935, p = 0.033) were independently
associated with VF.
Conclusion
HR-pQCT images detected differences in bone microstructure in older women with VF
independent of aBMD and TBS by DXA, and HR-pQCT could be a useful tool to assess fracture
risk. In men, femoral neck aBMD was associated with VF, and DXA continues to be an
important tool for predicting VF.
Abbreviations:
HR-pQCT (high-resolution peripheral quantitative computed tomography), TBS (trabecular bone score), VFA (vertebral fracture assessment), DXA (dual energy X-ray absorption), OR (odds ratio), VF (vertebral fractures), SP (strength parameters)Keywords
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Article info
Publication history
Published online: November 27, 2018
Accepted:
November 26,
2018
Received in revised form:
November 16,
2018
Received:
April 8,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
