Endogenous dehydroepiandrosterone levels and its derivatives modifies the association between total estradiol and type 2 diabetes risk in postmenopausal women: The Rotterdam Study

      Background and aims: Recent evidence indicates that higher levels of endogenous estradiol might be associated with increased risk of type 2 diabetes (T2D) in postmenopausal women. Dehydroepiandrosterone (DHEA) may influence the levels of estrogen in the body, and recently direct effects of DHEA on estrogen receptors have been shown. Also, higher levels of DHEA are associated with lower risk of developing T2D. However, it is not known whether DHEA levels may modify the effect of estradiol on T2D. We aimed to investigate the association between endogenous estradiol levels with T2D in postmenopausal women and to examine whether this association was modified by the levels of the endogenous DHEA steroid hormone and its derivatives.
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