Background and aims: Recent evidence indicates that higher levels of endogenous estradiol might be associated
with increased risk of type 2 diabetes (T2D) in postmenopausal women. Dehydroepiandrosterone
(DHEA) may influence the levels of estrogen in the body, and recently direct effects
of DHEA on estrogen receptors have been shown. Also, higher levels of DHEA are associated
with lower risk of developing T2D. However, it is not known whether DHEA levels may
modify the effect of estradiol on T2D. We aimed to investigate the association between
endogenous estradiol levels with T2D in postmenopausal women and to examine whether
this association was modified by the levels of the endogenous DHEA steroid hormone
and its derivatives.
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© 2017 Published by Elsevier Inc.
