Associations of endogenous estradiol and testosterone levels with plaque composition and risk of stroke in subjects with carotid atherosclerosis

      Background: Carotid atherosclerosis remains an important etiological factor of ischemic stroke. Sex differences have been observed in carotid plaque composition and in stroke incidence. Sex steroids have been suggested to count for these sex differences, but the evidence in humans is limited. Therefore, we aimed to study the associations of endogenous estradiol and testosterone with carotid plaque composition in middle-aged and elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population.
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