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Clinical evaluation of the NK3 receptor antagonist fezolinetant (a.k.a. ESN364) for the treatment of menopausal hot flashes

      Context: NK3 receptor (“NK3”; TACR3) signaling is implicated in the etiology of hot flashes by the clinical pharmacology of neurokinin B (NKB) [ ], neuroanatomical evidence for hypertrophy of NKB-expressing neurons in menopausal women [ ], and association between risk of vasomotor symptoms and genetic variation in TACR3 [ ]. Fezolinetant is an NK3 antagonist demonstrated to safely modulate hormone biomarkers in premenopausal women [
      • Fraser G.L.
      • et al.
      ]. Here, we present clinical trial results for fezolinetant in the treatment of menopausal hot flashes (“HF”).
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