Highlights
- •After menopause, there is a remarkable increase in the prevalence of insulin resistance and metabolic syndrome.
- •In this study, serum ferritin levels were positively associated with insulin resistance and metabolic syndrome in postmenopausal women.
- •Serum ferritin level in postmenopausal women may help to identify the presence of insulin resistance and metabolic syndrome.
Abstract
Objective
Serum ferritin, a marker of iron metabolism, has recently emerged as a biomarker of
chronic low-grade inflammation. After menopause, there is a remarkable increase in
insulin resistance (IR) and metabolic syndrome (MetS), which is increasingly being
viewed as an inflammatory disease. Thus, we examined the associations of serum ferritin
with insulin resistance and MetS in postmenopausal women.
Methods
A nationwide cross-sectional study was conducted to examine the relationship between
serum ferritin and IR and MetS in 2734 postmenopausal women using data from the 2010–2012
Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and
95% confidence intervals (CIs) for insulin resistance (HOMA-IR ≥ 75th percentile, 3.04) and MetS were calculated using multiple logistic regression
analyses across serum ferritin quartiles (Q1, ≤ 36.25; Q2, 36.56–56.56; Q3, 56.57–85.98; and Q4 ≥ 85.99 ng/ml).
Results
The mean values of most cardiometabolic variables tended to increase proportionally
with serum ferritin quartiles. The proportion of women with IR and MetS significantly
increased in accordance with serum ferritin quartiles. Compared to individuals in
the lowest quartile, the ORs (95% CIs) in the highest quartile were 2.06 (1.23–3.45)
for IR and 1.92 (1.44–2.55) for MetS after adjusting for age, cigarette smoking, alcohol
intake, and regular exercise.
Conclusion
Serum ferritin levels were positively and independently associated with IR and MetS
in postmenopausal women. These findings suggest that serum ferritin level in postmenopausal
women may help to identify the presence of IR and MetS.
Keywords
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Article info
Publication history
Published online: June 06, 2017
Accepted:
June 2,
2017
Received in revised form:
May 25,
2017
Received:
April 20,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
