Highlights
- •The evidence regarding an association of FOXO3A rs2802292 with extreme longevity is conflicting.
- •We found no significant association in two ethnically diverse populations.
- •The results were unchanged in sex-based analyses.
- •Further resequencing efforts of the FOXO3A gene are needed.
Abstract
Objectives
Previous studies have indicated that the rs2802292 polymorphism in the human forkhead
box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years),
although the results are conflicting.
Study design and main outcome measures
Using a case-control design, we investigated the distribution of the rs2802292 polymorphism
in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls).
The first cohort included Japanese individuals (733 centenarians and 820 controls)
and the second was from Northern Italy (79 disease-free centenarians and 316 controls).
Results
No statistically significant association was found between the rs2802292 polymorphism
and EL in either cohort (either examined in their entirety or in a sex-based analysis).
Conclusions
In light of our negative findings, further research and resequencing efforts are needed
to shed more light on the potential association between EL and FOXO3A polymorphisms.
Abbreviations:
EL (exceptional longevity), GWAS (genome-wide association studies), HWE (Hardy-Weinberg equilibrium), IGF-1 (insulin-like growth factor-1), IIS (insulin and IGF-1 signaling), NGS (next-generation sequencing), SNP (single nucleotide polymorphism), SSC-J (semi-supercentenarians study in Japan), TCS (Tokyo centenarians study)Keywords
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Article info
Publication history
Published online: July 29, 2016
Accepted:
July 26,
2016
Received in revised form:
July 24,
2016
Received:
June 23,
2016
Identification
Copyright
© 2016 Published by Elsevier Ireland Ltd.
