Highlights
- •Reference values are reported for 34 frequently used laboratory tests in 80-year-old men and women.
- •Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance.
- •Several of the reference interval limits were outside the 90% confidence interval of the reference intervals of Nordic Reference Interval Project (NORIP).
Abstract
Objectives
Reference values are usually based on blood samples from healthy individuals in the
age range 20–50 years. Most patients seeking health care are older than this reference
population. Many reference intervals are age dependent and there is thus a need to
have appropriate reference intervals also for elderly individuals.
Methods
We analyzed a group of frequently used laboratory tests in an 80-year-old population
(n = 531, 266 females and 265 males). The 2.5th and 97.5th percentiles for these markers
were calculated according to the International Federation of Clinical Chemistry guidelines
on the statistical treatment of reference values.
Results
Reference values are reported for serum alanine transaminase (ALT), albumin, alkaline
phosphatase, pancreatic amylase, apolipoprotein A1, apolipoprotein B, apolipoprotein
B/apolipoprotein A1 ratio, aspartate aminotransferase (AST), AST/ALT ratio, bilirubin,
calcium, calprotectin, cholesterol, HDL-cholesterol, creatinine kinase (CK), creatinine,
creatinine estimated GFR, C-reactive protein, cystatin C, cystatin C estimated GFR,
gamma-glutamyltransferase (GGT), iron, iron saturation, lactate dehydrogenase (LDH),
magnesium, phosphate, transferrin, triglycerides, urate, urea, zinc, hemoglobin, platelet
count and white blood cell count. The upper reference limit for creatinine and urea
was significantly increased while the lower limit for iron and albumin was decreased
in this elderly population in comparison with the population in the Nordic Reference
Interval Project (NORIP).
Conclusions
Reference values calculated from the whole population and a subpopulation without
cardiovascular disease showed strong concordance. Several of the reference interval
limits were outside the 90% confidence interval of NORIP.
Keywords
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Article info
Publication history
Published online: July 27, 2016
Accepted:
July 25,
2016
Received in revised form:
July 6,
2016
Received:
November 23,
2015
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
