Whereas smart people enjoy many advantages including their longer and healthier lives,
older men are not well-known for taking care of their health. Eubie Blake’s humour
reveals a lifetime of ignorance about his right or wrong health choices. He showed
with wit that these may not become personally relevant until old age. Although older
adults are sometimes more fearful of dementia than they are of cancer or stroke, few
are aware of those life style choices that could have lowered their personal dementia
risk. Current trials try to find ways to promote brain protection against age-related
neurodegenerative diseases. For the most frequent forms of late onset dementia, these
trials no longer “clutch at straws”. Investigation of potentially modifiable dementia
risk factors means that life course-based brain protection strategies are now on firmer
ground and should be accepted as soundly-based [
[1]
]. Most available effective interventions are largely “multidomain approaches” with
potential to reduce dementia prevalence at a population level. Could an emphasis on
life course approaches be more successful if sexes were treated separately?- Winblad B.
- Amouyel P.
- Andrieu S.
- Ballard C.
- Brayne C.
- Brodaty H.
- Cedazo-Minguez A.
- Dubois B.
- Edvardsson D.
- Feldman H.
- Fratiglioni L.
- Frisoni G.B.
- Gauthier S.
- Georges J.
- Graff C.
- Iqbal K.
- Jessen F.
- Johansson G.
- Jönsson L.
- Kivipelto M.
- Knapp M.
- Mangialasche F.
- Melis R.
- Nordberg A.
- Rikkert M.O.
- Qiu C.
- Sakmar T.P.
- Scheltens P.
- Schneider L.S.
- Sperling R.
- Tjernberg L.O.
- Waldemar G.
- Wimo A.
- Zetterberg H.
Defeating Alzheimer’s disease and other dementias: a priority for European science
and society.
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References
- Defeating Alzheimer’s disease and other dementias: a priority for European science and society.Lancet Neurol. 2016; 15: 455-532https://doi.org/10.1016/S1474-4422(16)00062-4
- Differences in common genetic predisposition to ischemic stroke by age and sex.Stroke. 2015; 46: 3042-3047https://doi.org/10.1161/STROKEAHA.115.009816
- Sex differences in the clinical manifestations of Alzheimer disease pathology.Arch. Gen. Psychiatry. 2005; 62: 685-691https://doi.org/10.1001/archpsyc.62.6.685
- Age, APOE and sex: triad of risk of Alzheimer’s disease.J. Steroid Biochem. Mol. Biol. 2016; 160: 134-147
- Cognitive function and ageing studies (CFAS) collaboration. A two decade dementia incidence comparison from the cognitive function and ageing studies I and II.Nat. Commun. 2016; 19: 11398https://doi.org/10.1038/ncomms11398
Article info
Publication history
Published online: July 01, 2016
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© 2016 Published by Elsevier Ireland Ltd.
