Highlights
- •We examined the relationship between leukocyte counts and sarcopenia in 2152post-menopausal Korean women who participated in the 2010–2011 Korean National Health Examination and Nutrition Survey.
- •Leukocyte counts were positively related to a higher risk of sarcopenia in postmenopausal women.
- •Leukocyte counts may be another useful predictor of sarcopenia in postmenopausal women.
Abstract
Objective
To investigate the association between leukocyte counts and sarcopenia according in
postmenopausal women.
Study design
Cross-sectional study.
Main outcome and measures
We examined the relationship between leukocyte counts and sarcopenia in 2152 post-menopausal
Korean women who participated in the 2010–2011 Korean National Health Examination
and Nutrition Survey. Sarcopenia was defined as an appendicular skeletal muscle mass
(ASM) divided by weight (%) that was greater than 1 SD below the mean of young adults. The odds ratios (ORs) for sarcopenia were calculated
using multiple logistic regression across leukocyte count quartiles (Q1:≤4710, Q2:4720–5600, Q3:5610–6600, and Q4:≥6610 cells/μL) after adjusting for confounding variables.
Results
The prevalence of sarcopenia gradually increased in accordance with leukocyte quartiles.
Compared with the lowest quartile of leukocyte counts, the corresponding OR (95% CI)
of the highest quartile of leukocyte counts for sarcopenia was 2.41 (1.12–5.22) after
adjusting for age, waist circumference, cigarette smoking, alcohol intake, regular
exercise, blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol.
Conclusions
Leukocyte counts were positively related to a higher risk of sarcopenia in postmenopausal
women.
Keywords
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References
- Sarcopenia: origins and clinical relevance.Clin. Geriatr. Med. 2011; 27: 337-339
- Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.J. Am. Geriatr. Soc. 2002; 50: 889-896
- Muscle strength and quality are associated with severity of menopausal symptoms in peri- and post-menopausal women.Maturitas. 2013; 76: 88-94
- Sarcopenia and sarcopenic leg as potential risk factors for acute osteoporotic vertebral fracture among older women.Eur. Spine J. 2015;
- Relationship between postmenopausal osteoporosis and the components of clinical sarcopenia.Maturitas. 2013; 75: 175-180
- Skeletal muscle and bone: effect of sex steroids and aging.Adv. Physiol. Educ. 2008; 32: 120-126
- Inflammatory markers and physical performance in older persons: the InCHIANTI study.J. Gerontol. A Biol. Sci. Med. Sci. 2004; 59: 242-248
- Inflammatory markers and loss of muscle mass (sarcopenia) and strength.Am. J. Med. 2006; 119 (526): e9-17
- White blood-cell count and the risk of impaired fasting glucose or type II diabetes in middle-aged Japanese men.Diabetologia. 2002; 45: 42-48
- Elevated white blood cell count is associated with arterial stiffness.Nutr. Metab. Cardiovasc. Dis. 2009; 19: 3-7
- Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.Diabetologia. 1985; 28: 412-419
- Sarcopenia, obesity, and inflammation-results from the trial of angiotensin converting enzyme inhibition and novel cardiovascular risk factors study.Am. J. Clin. Nutr. 2005; 82: 428-434
- Finding good biomarkers for sarcopenia.J. Cachexia Sarcopenia Muscle. 2012; 3: 145-148
- Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on sarcopenia.J. Cachexia Sarcopenia Muscle. 2012; 3: 181-190
- Cancer cachexia: understanding the molecular basis.Nat. Rev. Cancer. 2014; 14: 754-762
- Intensity and amount of physical activity in relation to insulin sensitivity: the insulin resistance atherosclerosis study.Jama. 1998; 279: 669-674
- Appendicular skeletal muscle mass and insulin resistance in an elderly Korean population: the Korean social life, health and aging project-health examination cohort.Diabetes Metab. J. 2015; 39: 37-45
- Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the health ABC study.J. Gerontol. A Biol. Sci. Med. Sci. 2002; 57: M326-32
- Proinflammatory cytokines, aging, and age-related diseases.J. Am. Med. Dir. Assoc. 2013; 14: 877-882
- Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.J. Gerontol. A Biol. Sci. Med. Sci. 2012; 67: 671-676
- Serum IL-6 level and the development of disability in older persons.J. Am. Geriatr. Soc. 1999; 47: 639-646
- Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women.J. Clin. Endocrinol. Metabol. 2003; 88: 2019-2025
- Epidemiology of sarcopenia among the elderly in New Mexico.Am. J. Epidemiol. 1998; 147: 755-763
- Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean longitudinal study on health and aging (KLoSHA).Diabetes Care. 2010; 33: 1652-1654
- Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people.Age Ageing. 2010; 39: 412-423
Article info
Publication history
Published online: November 25, 2015
Accepted:
November 21,
2015
Received in revised form:
November 20,
2015
Received:
September 24,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
