Abstract
Vitamin E is known to be the most important antioxidant in the body, protecting against
the effects of toxic radicals. The main idea behind the studies on vitamin E and bone
metabolism stems from the concept that oxidative stress may interfere with the bone
formation activity of osteoblasts which in turn can lead to osteoporosis. This mini-review,
summarizes the studies on the effects of vitamin E on bone mineral density, fracture
risk, bone formation, and resorption markers in perimenopausal women. Current evidence
does not the support daily use of vitamin E for protection against osteoporosis and
hip fracture risk in perimenopausal women. However some benefit has been shown in
some observational studies. Low vitamin E (>6.2 mg/day) intake seems to be associated with an OR of 3.0 of hip fracture in current
smokers. Compared with the highest quintile of alpha-tocopherol intake, the lowest
quintile of intake conferred a multivariable-adjusted HR of 1.86 for hip fracture
and 1.20 for any fracture. Alpha-tocopherol supplementation may alter the alpha-tocopherol/gamma-tocopherol
ratio; which in turn may be associated with decreased osteoblastic activity. Interventional
studies, especially randomized controlled trials (RCT), evaluating a possible causal
relationship between serum vitamin E levels and BMD and hip fracture risk in perimenopausal
women are needed.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to MaturitasAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- A review of select vitamins and minerals used by postmenopausal women.Maturitas. 2010; 66: 370-380
- Effects of tocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis.Evid Based Complement Alternat Med. 2012; 2012: 960742
- Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model.Evid Based Complement Alternat Med. 2012; 2012: 161527
- Effects of α-tocopherol on the early phase of osteoporotic fracture healing.J Orthop Res. 2011; 29: 1732-1738
- Effects of vitamin E on the osteoblast differentiation.J Vet Med Sci. 2010; 72: 951-957
- Effects of low-dose versus high-dose γ-tocotrienol on the bone cells exposed to the hydrogen peroxide-induced oxidative stress and apoptosis.Evid Based Complement Alternat Med. 2012; 2012: 680834
- γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor.Bone. 2014; (July 11) pii: S8756-3282(14)00258-0. [Epub ahead of print]https://doi.org/10.1016/j.bone.2014.07.006
- Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis.Indian J Clin Biochem. 2007; 22: 101-105
- Smoking, antioxidant vitamins, and the risk of hip fracture.J Bone Miner Res. 1999; 14: 129-135
- Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids.Am J Clin Nutr. 2004; 79: 155-165
- Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the women's health initiative.Am J Clin Nutr. 2005; 82: 581-588
- Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study.J Bone Miner Metab. 2013; 31: 455-460
- Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.J Clin Endocrinol Metab. 2003; 88: 1523-1527
- Effects of vitamin E on bone turnover markers among US postmenopausal women.J Bone Miner Res. 2012; 27: 1368-1380
- Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status.Am J Epidemiol. 2006; 163: 9-17
- Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.Am J Clin Nutr. 2014; 99: 107-114
Article info
Publication history
Published online: September 06, 2014
Accepted:
August 29,
2014
Received:
August 20,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
