Mini Review| Volume 79, ISSUE 4, P476-480, December 2014

Effects of vitamin E on bone remodeling in perimenopausal women: Mini review

  • Onur Guralp
    Corresponding author at: Akademiler Sit. B/37, Kat. 8 Beşiktaş, Istanbul, Turkey. Tel.: +90 5066319529; fax: +90 2123226955.
    Obstetrics and Gynecology, Bozova State Hospital, Sanliurfa, Turkey
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Published:September 06, 2014DOI:


      Vitamin E is known to be the most important antioxidant in the body, protecting against the effects of toxic radicals. The main idea behind the studies on vitamin E and bone metabolism stems from the concept that oxidative stress may interfere with the bone formation activity of osteoblasts which in turn can lead to osteoporosis. This mini-review, summarizes the studies on the effects of vitamin E on bone mineral density, fracture risk, bone formation, and resorption markers in perimenopausal women. Current evidence does not the support daily use of vitamin E for protection against osteoporosis and hip fracture risk in perimenopausal women. However some benefit has been shown in some observational studies. Low vitamin E (>6.2 mg/day) intake seems to be associated with an OR of 3.0 of hip fracture in current smokers. Compared with the highest quintile of alpha-tocopherol intake, the lowest quintile of intake conferred a multivariable-adjusted HR of 1.86 for hip fracture and 1.20 for any fracture. Alpha-tocopherol supplementation may alter the alpha-tocopherol/gamma-tocopherol ratio; which in turn may be associated with decreased osteoblastic activity. Interventional studies, especially randomized controlled trials (RCT), evaluating a possible causal relationship between serum vitamin E levels and BMD and hip fracture risk in perimenopausal women are needed.


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        • Dennehy C.
        • Tsourounis C.
        A review of select vitamins and minerals used by postmenopausal women.
        Maturitas. 2010; 66: 370-380
        • Abdul-Majeed S.
        • Mohamed N.
        • Soelaiman I.N.
        Effects of tocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis.
        Evid Based Complement Alternat Med. 2012; 2012: 960742
        • Muhammad N.
        • Luke D.A.
        • Shuid A.N.
        • Mohamed N.
        • Soelaiman I.N.
        Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model.
        Evid Based Complement Alternat Med. 2012; 2012: 161527
        • Shuid A.N.
        • Mohamad S.
        • Muhammad N.
        • Fadzilah F.M.
        • Mokhtar S.A.
        • Mohamed N.
        • et al.
        Effects of α-tocopherol on the early phase of osteoporotic fracture healing.
        J Orthop Res. 2011; 29: 1732-1738
        • Soeta S.
        • Higuchi M.
        • Yoshimura I.
        • Itoh R.
        • Kimura N.
        • Aamsaki H.
        Effects of vitamin E on the osteoblast differentiation.
        J Vet Med Sci. 2010; 72: 951-957
        • Abd Manan N.
        • Mohamed N.
        • Shuid A.N.
        Effects of low-dose versus high-dose γ-tocotrienol on the bone cells exposed to the hydrogen peroxide-induced oxidative stress and apoptosis.
        Evid Based Complement Alternat Med. 2012; 2012: 680834
        • Deng L.
        • Ding Y.
        • Peng Y.
        • Wu Y.
        • Fan J.
        • Li W.
        • et al.
        γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor.
        Bone. 2014; (July 11) pii: S8756-3282(14)00258-0. [Epub ahead of print]
        • Chavan S.N.
        • More U.
        • Mulgund S.
        • Saxena V.
        • Sontakke A.N.
        Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis.
        Indian J Clin Biochem. 2007; 22: 101-105
        • Melhus H.
        • Michaelsson K.
        • Holmberg L.
        • Wolk A.
        • Ljunghall S.
        Smoking, antioxidant vitamins, and the risk of hip fracture.
        J Bone Miner Res. 1999; 14: 129-135
        • Macdonald H.M.
        • New S.A.
        • Golden M.H.
        • Campbell M.K.
        • Reid D.M.
        Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids.
        Am J Clin Nutr. 2004; 79: 155-165
        • Wolf R.L.
        • Cauley J.A.
        • Pettinger M.
        • Jackson R.
        • Lacroix A.
        • Leboff M.S.
        • et al.
        Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the women's health initiative.
        Am J Clin Nutr. 2005; 82: 581-588
        • Mata-Granados J.M.
        • Cuenca-Acebedo R.
        • Luque de Castro M.D.
        • Quesada Gomez J.M.
        Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study.
        J Bone Miner Metab. 2013; 31: 455-460
        • Maggio D.
        • Barabani M.
        • Pierandrei M.
        • Polidori M.C.
        • Catani M.
        • Mecocci P.
        • et al.
        Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
        J Clin Endocrinol Metab. 2003; 88: 1523-1527
        • Hamidi M.S.
        • Corey P.N.
        • Cheung A.M.
        Effects of vitamin E on bone turnover markers among US postmenopausal women.
        J Bone Miner Res. 2012; 27: 1368-1380
        • Zhang J.
        • Munger R.G.
        • West N.A.
        • Cutler D.R.
        • Wengreen H.J.
        • Corcoran C.D.
        Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status.
        Am J Epidemiol. 2006; 163: 9-17
        • Michaëlsson K.
        • Wolk A.
        • Byberg L.
        • Ärnlöv J.
        • Melhus H.
        Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.
        Am J Clin Nutr. 2014; 99: 107-114