Highlights
- •OAB women have more psychological distress, neuroticism, and introversion than non-OAB women.
- •Antimuscarinics could improve anxiety.
- •Antimuscarinics could improve global psychological distress.
Abstract
Objectives
To investigate the characteristics of psychological distress (PD), personality traits,
and family support in women with overactive bladder syndrome (OAB), and the effects
of antimuscarinic treatment.
Study design
Women with and without OAB (age- and body mass index [BMI]-matched control group)
were prospectively enrolled; they recorded bladder diaries, underwent urodynamic studies,
and completed PD, personality traits, and filled family support questionnaires before
and after antimuscarinic treatment. OAB women underwent treatment with tolterodine
or solifenacin for 12 weeks. The control group completed questionnaires.
Main outcome measures
The differences in PD, personality traits, and family support scores between both
groups, and the changes after antimuscarinic treatment in OAB women.
Results
Eighty-five women with OAB (tolterodine, n = 42; solifenacin, n = 43) and 65 without OAB completed the studies. Linear regression analysis with age
and BMI adjustment revealed: coefficients of OAB were significant (all P < 0.05) for somatic complaints (mean: 0.87 vs. 0.63, coefficient = 0.21), obsessive–compulsive symptoms (0.69 vs. 0.44, coefficient = 0.25), anxiety symptoms (0.42 vs. 0.27, coefficient = 0.14), General Symptom Index (GSI, 0.48 vs. 0.33, coefficient = 0.14), neuroticism (9.23 vs. 5.17, coefficient = 3.73), and extroversion–introversion (13.64 vs. 15.25, coefficient = −1.73). Anxiety symptoms (0.42 vs. 0.36) and GSI (0.48 vs. 0.39) improved after antimuscarinics
(all P < 0.05). High Overactive Bladder Symptom Score questionnaire score (coefficient = −0.39), low hostility score (coefficient = 2.11), and high additional symptoms score (coefficient = −1.46) were associated with good therapeutic effect (all P < 0.05).
Conclusions
OAB women experience more PD, neuroticism, and introversion than asymptomatic women,
and antimuscarinics could improve PD.
Keywords
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Article info
Publication history
Published online: September 03, 2014
Accepted:
August 14,
2014
Received in revised form:
August 9,
2014
Received:
May 21,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
