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Muscle strength and quality are associated with severity of menopausal symptoms in peri- and post-menopausal women

  • Jee-Yon Lee
    Affiliations
    Department of Family Medicine, Severance Hospital, Yonsei University, College of Medicine, 250 Seongsanno, Seodaemun-gu 120-752, Republic of Korea
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  • Duk-Chul Lee
    Correspondence
    Corresponding author. Tel.: +82 2 2228 2330; fax: +82 2 362 2473.
    Affiliations
    Department of Family Medicine, Severance Hospital, Yonsei University, College of Medicine, 250 Seongsanno, Seodaemun-gu 120-752, Republic of Korea
    Search for articles by this author

      Abstract

      Objectives

      Menopausal symptoms are common and affect the quality of life of menopausal women. Menopausal symptoms are associated with age-related conditions. Sarcopenia, loss of muscle mass and/or function, is also associated with several age-related conditions, suggesting that the severity of menopausal symptoms may be associated with sarcopenia. Therefore, we investigated the relationship between Kupperman index scores, a measure of menopausal symptom severity, and muscle strength and quality in peri- and post-menopausal women.

      Study design

      Cross-sectional study.

      Main outcome measures

      A total of 148 women participated. Biomarkers of metabolic risk factors were assessed along with muscle mass as measured with Dual-energy X-ray Absorptiometry. Handgrip strength was measured with isometric dynamometry. Muscle quality was calculated as the ratio of strength to muscle mass in upper extremities.

      Results

      Kupperman index scores correlated with the depression scale, handgrip strength, and specific force after adjusting for age and body mass index. Mean handgrip strength and specific force decreased gradually according to menopausal symptom severity. Multivariate logistic regression analysis showed that the fourth handgrip strength and specific force quartiles were associated with the prevalence of severe menopausal symptoms with adjusted odds ratios of 0.14 (95% confidence interval 0.03–0.68) and 0.09 (95% confidence interval 0.03–0.47), respectively.

      Conclusions

      Lower handgrip strength was associated with severe menopausal symptoms. Although we could not determine causality, muscle strength and quality during menopause may be related to the severity of menopausal symptoms. Further interventional and experimental studies are required to understand the clinical and pathophysiological significance of our findings.

      Keywords

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      References

        • Dennerstein L.
        • Dudley E.C.
        • Hopper J.L.
        • Guthrie J.R.
        • Burger H.G.
        A prospective population-based study of menopausal symptoms.
        Obstetrics & Gynecology. 2000; 96: 351-358
        • Elavsky S.
        • McAuley E.
        Physical activity, symptoms, esteem, and life satisfaction during menopause.
        Maturitas. 2005; 52: 374-385
        • Daly E.
        • Gray A.
        • Barlow D.
        • McPherson K.
        • Roche M.
        • Vessey M.
        Measuring the impact of menopausal symptoms on quality of life.
        BMJ: British Medical Journal. 1993; 307: 836
        • Pérez J.M.
        • Palacios S.
        • Chavida F.
        • Pérez M.
        Severity of menopausal symptoms and cardiovascular and osteoporosis risk factors.
        Climacteric. 2012; : 1-9
        • Lee S.W.
        • Jo H.H.
        • Kim M.R.
        • Kwon D.J.
        • You Y.O.
        • Kim J.H.
        Association between menopausal symptoms and metabolic syndrome in postmenopausal women.
        Archives of Gynecology and Obstetrics. 2012; 285: 541-548
        • Avis N.E.
        • Crawford S.L.
        • McKinlay S.M.
        Psychosocial, behavioral, and health factors related to menopause symptomatology.
        Women's Health (Hillsdale, NJ). 1997; 3
        • Drey M.
        Sarcopenia–pathophysiology and clinical relevance.
        WMW Wiener Medizinische Wochenschrift. 2011; 161: 402-408
        • Metter E.J.
        • Talbot L.A.
        • Schrager M.
        • Conwit R.
        Skeletal muscle strength as a predictor of all-cause mortality in healthy men.
        Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2002; 57: B359-B365
        • Newman A.B.
        • Kupelian V.
        • Visser M.
        • et al.
        Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort.
        Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006; 61: 72-77
        • Barbat-Artigas S.
        • Dupontgand S.
        • Fex A.
        • Fabre J.
        • Karelis A.
        • Aubertin-Leheudre M.
        Op011 relationship between dynapenia and cardio-respiratory function in healthy postmenopausal women: a novel clinical criteria.
        Clinical Nutrition Supplements. 2010; 5: 5
        • Metter E.J.
        • Lynch N.
        • Conwit R.
        • Lindle R.
        • Tobin J.
        • Hurley B.
        Muscle quality and age: cross-sectional and longitudinal comparisons.
        Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 1999; 54: B207-B218
        • Janssen I.
        • Heymsfield S.B.
        • Ross R.
        Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.
        Journal of the American Geriatrics Society. 2002; 50: 889-896
        • Cho M.J.
        • Bae J.N.
        • Suh G.H.
        • et al.
        Validation of geriatric depression scale, Korean version (GDS) in the assessment of DSM-III-R major depression.
        Journal of Korean Neuropsychiatric Association. 1999; 38: 48-63
        • Kupperman H.S.
        • Wetchler B.B.
        • Blatt M.H.
        Contemporary therapy of the menopausal syndrome.
        Journal of the American Medical Association. 1959; 171: 1627-1637
        • Ruiz-Ruiz J.
        • Mesa J.L.
        • Gutiérrez A.
        • Castillo M.J.
        Hand size influences optimal grip span in women but not in men.
        Journal of Hand Surgery. 2002; 27: 897-901
        • Newman A.B.
        • Haggerty C.L.
        • Goodpaster B.
        • et al.
        Strength and muscle quality in a well-functioning cohort of older adults: the health, aging and body composition study.
        Journal of the American Geriatrics Society. 2003; 51: 323-330
        • Barbat-Artigas S.
        • Rolland Y.
        • Zamboni M.
        • Aubertin-Leheudre M.
        How to assess functional status: a new muscle quality index.
        Journal of Nutrition, Health & Aging. 2012; 16: 67-77
        • Davison S.
        • Bell R.
        • Donath S.
        • Montalto J.
        • Davis S.
        Androgen levels in adult females: changes with age, menopause, and oophorectomy.
        Journal of Clinical Endocrinology & Metabolism. 2005; 90: 3847-3853
        • Maggio M.
        • Lauretani F.
        • Ceda G.P.
        Sex hormones and sarcopenia in older persons.
        Current Opinion in Clinical Nutrition & Metabolic Care. 2013; 16: 3-13
        • Jacobsen D.
        • Samson M.
        • Kezic S.
        • Verhaar H.
        Postmenopausal HRT and tibolone in relation to muscle strength and body composition.
        Maturitas. 2007; 58: 7-18
        • Enea C.
        • Boisseau N.
        • Fargeas-Gluck M.A.
        • Diaz V.
        • Dugué B.
        Circulating androgens in women.
        Sports Medicine. 2011; 41: 1-15
        • Sudhir K.
        • Esler M.D.
        • Jennings G.L.
        • Komesaroff P.A.
        Estrogen supplementation decreases norepinephrine-induced vasoconstriction and total body norepinephrine spillover in perimenopausal women.
        Hypertension. 1997; 30: 1538-1543
        • Lobo R.A.
        • Kelsey J.L.
        • Marcus R.
        Menopause: biology and pathobiology.
        1st ed. Academic Press, California2000
        • Sarrel P.M.
        Androgen deficiency: menopause and estrogen-related factors.
        Fertility and Sterility. 2002; 77: 63-67
        • Doria E.
        • Buonocore D.
        • Focarelli A.
        • Marzatico F.
        Relationship between human aging muscle and oxidative system pathway.
        Oxidative Medicine and Cellular Longevity. 2012; 2012: 13
        • Laufs U.
        • Wassmann S.
        • Czech T.
        • et al.
        Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
        Arteriosclerosis, Thrombosis, and Vascular Biology. 2005; 25: 809-814
        • Stirone C.
        • Duckles S.P.
        • Krause D.N.
        • Procaccio V.
        Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels.
        Molecular Pharmacology. 2005; 68: 959-965
        • Van Der Schouw Y.T.
        • Grobbee D.E.
        Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of post-menopausal hormone therapy.
        European Heart Journal. 2005; 26: 1358-1361
        • Andersen J.L.
        Muscle fibre type adaptation in the elderly human muscle.
        Scandinavian Journal of Medicine & Science in Sports. 2003; 13: 40-47
        • Rantanen T.
        • Era P.
        • Heikkinen E.
        Maximal isometric strength and mobility among 75-year-old men and women.
        Age and Ageing. 1994; 23: 132-137

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