Abstract
Purpose
The aim of the study was to determine the relationship between the components of clinical
sarcopenia and osteoporosis in postmenopausal women.
Methods
A population-based cohort of 590 Finnish postmenopausal women (mean age 67.9; range
65–72) was selected from the Osteoporosis Fracture Prevention (OSTPRE-FPS) study in
2002. Bone mineral density (BMD) and lean tissue mass were assessed by dual X-ray
absorptiometry (DXA). The study sample was divided into three categories according
to the WHO BMD classification: normal, osteopenia and osteoporosis. The study sample
was divided into non-sarcopenic, presarcopenic, sarcopenic and non-classified groups
according to quartiles of RSMI i.e. relative skeletal muscle index (appendicular muscle
mass (kg)/square of height (m)), hand grip strength (kPa) and walking speed.
Results
In logistic regression analysis sarcopenic women had 12.9 times higher odds of having
osteoporosis (p ≤ 0.001, OR = 12.9; 95% CI = 3.1–53.5) in comparison to non-sarcopenic women. In comparison to women in the highest
grip strength quartile, women within the lowest quartile had 11.7 times higher odds
of having osteoporosis (p = 0.001, OR = 11.7; 2.6–53.4). Sarcopenic women had 2.7 times higher odds of having fractures than
their non-sarcopenic counterparts (p = 0.005, OR = 2.732; 1.4–5.5). Sarcopenic women had also 2.1 times higher risk of falls during the
preceding 12 months compared to non-sarcopenic women (p = 0.021, OR = 2.1; 1.1–3.9). Adjustment for age, body mass index (BMI), physical activity and hormone
therapy (HT) did not significantly alter these results.
Conclusions
The components of clinical sarcopenia are strongly associated with osteoporosis. Grip
strength is the most significant measurement to reveal the association between sarcopenia
and osteoporosis, falls and fractures.
Keywords
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Article info
Publication history
Published online: April 11, 2013
Accepted:
March 25,
2013
Received in revised form:
March 21,
2013
Received:
December 17,
2012
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
