Abstract
Objectives
To determine the contribution of life style and health related factors on vitamin
D status in middle-aged and older men and women.
Study design
A cross-sectional single-center study in 400 male subjects (40–80 years) and 402 postmenopausal
female subjects (56–73 years), conducted in a University Medical Center in the central
part of the Netherlands (52 degrees northern latitude).
Main outcome measures
Medical history, vitamin D, calcium and alcohol intake, physical activity, Body Mass
Index, Blood pressure, smoking, total fat body mass and total lean body mass were
measured using DEXA. Laboratory analysis included 25-hydroxyvitamin D (25OHD) and
sex hormones.
Results
Thirty-six percent of men and 51% of women had 25OHD less than 50 nmol/L. In summertime men had significant higher 25OHD as compared to women (81.5
vs 53.3 nmol/L, P = .000) but this difference disappeared come winter. In a saturated model, male gender
(B = .16, P = .008), and season (summer vs winter B = .30, P = .000) remained statistically significant. In men, physical activity and season explained
21% of the variance. In women, household physical activity (B = .13, P = .03), sport physical activity (B = .02, P = .02) and estradiol (B = −.003, P = .048) remained in the model,.
Conclusion
In healthy middle-aged and older men and postmenopausal women, male gender and season
were important predictors of vitamin D status. In men, physically activity and season,
explained 21% of the variance in vitamin D status. In women, physical activity and
estradiol explained 9.3% of the variance in vitamin D.
Keywords
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Article info
Publication history
Published online: November 21, 2012
Accepted:
October 17,
2012
Received:
October 12,
2012
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
