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Research Article| Volume 74, ISSUE 1, P26-30, January 2013

Menopause, hormone treatment and urinary incontinence at midlife

  • Guillaume Legendre
    Affiliations
    INSERM UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, U1018, Gender, Sexual and Reproductive Health Team, Paris-Sud University, Villejuif, France

    Institut National des Etudes Démographiques, Paris, France

    Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France
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  • Virginie Ringa
    Affiliations
    INSERM UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, U1018, Gender, Sexual and Reproductive Health Team, Paris-Sud University, Villejuif, France

    Institut National des Etudes Démographiques, Paris, France
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  • Arnaud Fauconnier
    Affiliations
    Research unit EA 7285, Versailles-St-Quentin University, Montigny-le-Bretonneux, France

    Poissy-Saint-Germain-en-Laye Hospital, Poissy, France
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  • Xavier Fritel
    Correspondence
    Corresponding author at: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, CHU de Poitiers, 2 rue de la Milétrie, F-86000 Poitiers, France. Tel.: +33 549 443 360; fax: +33 549 443 910.
    Affiliations
    INSERM CIC0802, Poitiers University Hospital, Poitiers University, France

    INSERM UMR S953, Epidemiological Research on Perinatal Health and Women and Children Health, Paris 6 University, Paris, France
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      Abstract

      Whether there is any association between urinary incontinence and menopause is the subject of debate, partly due to the fact it is difficult to tell the difference between the effects of menopause and those of ageing. For some time it was hoped that hormonal treatment for menopause would be beneficial for urinary incontinence because there are hormonal receptors in the urinary tract. The goal of this survey of current knowledge on the subject is to explore thoroughly the relationship between menopause and urinary incontinence.
      Our study is based on a review of the literature dealing with the epidemiology of urinary incontinence in women aged between 45 and 60, and the effects of hormonal treatment with respect to the symptoms of involuntary loss of urine.
      Analysis of the epidemiological data drawn from large cohorts shows that on the one hand, the menopause has little if any impact on the risk of urinary incontinence, and on the other hand that the effects of oestrogen medication on urinary incontinence vary according to how it is administered and the type of incontinence. The effect of oral hormone treatments for menopause is rather negative with respect to stress incontinence. Vaginal treatment appears to be beneficial for overactive bladder symptoms.

      Keywords

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      References

        • Melby M.K.
        • Lock M.
        • Kaufert P.
        Culture and symptom reporting at menopause.
        Human Reproduction Update. 2005; 11: 495-512
        • Nelson H.D.
        Menopause.
        Lancet. 2008; 371: 760-770
        • Delanoe D.
        • Hajri S.
        • Bachelot A.
        • et al.
        Class, gender and culture in the experience of menopause. A comparative survey in Tunisia and France.
        Social Science & Medicine. 2012; 75: 401-409
        • Haylen B.T.
        • de Ridder D.
        • Freeman R.M.
        • et al.
        An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction.
        Neurourology and Urodynamics. 2010; 29: 4-20
        • Bartoli S.
        • Aguzzi G.
        • Tarricone R.
        Impact on quality of life of urinary incontinence and overactive bladder: a systematic literature review.
        Urology. 2010; 75: 491-500
        • Saadoun K.
        • Ringa V.
        • Fritel X.
        • Varnoux N.
        • Zins M.
        • Breart G.
        Negative impact of urinary incontinence on quality of life, a cross-sectional study among women aged 49–61 years enrolled in the GAZEL cohort.
        Neurourology and Urodynamics. 2006; 25: 696-702
        • Menezes M.
        • Pereira M.
        • Hextall A.
        Predictors of female urinary incontinence at midlife and beyond.
        Maturitas. 2009; 65: 167-171
        • Robinson D.
        • Cardozo L.
        Estrogens and the lower urinary tract.
        Neurourology and Urodynamics. 2011; 30: 754-757
        • Berecki-Gisolf J.
        • Begum N.
        • Dobson A.J.
        Symptoms reported by women in midlife: menopausal transition or aging?.
        Menopause. 2009; 16: 1021-1029
        • Quinn S.D.
        • Domoney C.
        The effects of hormones on urinary incontinence in postmenopausal women.
        Climacteric. 2009; 12: 106-113
        • Ewies A.A.
        • Alfhaily F.
        Topical vaginal estrogen therapy in managing postmenopausal urinary symptoms: a reality or a gimmick?.
        Climacteric. 2010; 13: 405-418
        • Kobata S.A.
        • Girao M.J.
        • Baracat E.C.
        • et al.
        Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Doppler velocimetry analysis.
        Maturitas. 2008; 61: 243-247
        • Jarmy-Di Bella Z.I.
        • Girao M.J.
        • Di Bella V.
        • et al.
        Hormonal influence on periurethral vessels in postmenopausal incontinent women using Doppler velocimetry analysis.
        Maturitas. 2007; 56: 297-302
        • Hannestad Y.S.
        • Rortveit G.
        • Sandvik H.
        • Hunskaar S.
        A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of incontinence in the county of Nord-Trondelag.
        Journal of Clinical Epidemiology. 2000; 53: 1150-1157
        • Sherburn M.
        • Guthrie J.R.
        • Dudley E.C.
        • O’Connell H.E.
        • Dennerstein L.
        Is incontinence associated with menopause?.
        Obstetrics and Gynecology. 2001; 98: 628-633
        • McGrother C.W.
        • Donaldson M.M.
        • Shaw C.
        • et al.
        Storage symptoms of the bladder: prevalence, incidence and need for services in the UK.
        BJU International. 2004; 93: 763-769
        • Hagglund D.
        • Walker-Engstrom M.L.
        • Larsson G.
        • Leppert J.
        Changes in urinary incontinence and quality of life after four years. A population-based study of women aged 22–50 years.
        Scandinavian Journal of Primary Health Care. 2004; 22: 112-117
        • Moller L.A.
        • Lose G.
        • Jorgensen T.
        Incidence and remission rates of lower urinary tract symptoms at one year in women aged 40–60: longitudinal study.
        British Medical Journal. 2000; 320: 1429-1432
        • Townsend M.K.
        • Danforth K.N.
        • Lifford K.L.
        • et al.
        Incidence and remission of urinary incontinence in middle-aged women.
        American Journal of Obstetrics and Gynecology. 2007; 197: 167e1-1675e
        • Samuelsson E.C.
        • Victor F.T.
        • Svardsudd K.F.
        Five-year incidence and remission rates of female urinary incontinence in a Swedish population less than 65 years old.
        American Journal of Obstetrics and Gynecology. 2000; 183: 568-574
        • Waetjen L.E.
        • Ye J.
        • Feng W.Y.
        • et al.
        Association between menopausal transition stages and developing urinary incontinence.
        Obstetrics and Gynecology. 2009; 114: 989-998
        • Waetjen L.E.
        • Feng W.Y.
        • Ye J.
        • et al.
        Factors associated with worsening and improving urinary incontinence across the menopausal transition.
        Obstetrics and Gynecology. 2008; 111: 667-677
        • Mishra G.D.
        • Cardozo L.
        • Kuh D.
        Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort.
        BJU International. 2010; 106: 1170-1175
        • Zhu L.
        • Lang J.
        • Liu C.
        • Han S.
        • Huang J.
        • Li X.
        The epidemiological study of women with urinary incontinence and risk factors for stress urinary incontinence in China.
        Menopause. 2009; 16: 831-836
        • Gopal M.
        • Sammel M.D.
        • Arya L.A.
        • Freeman E.W.
        • Lin H.
        • Gracia C.
        Association of change in estradiol to lower urinary tract symptoms during the menopausal transition.
        Obstetrics and Gynecology. 2008; 112: 1045-1052
        • Waetjen L.E.
        • Johnson W.O.
        • Xing G.
        • Feng W.Y.
        • Greendale G.A.
        • Gold E.B.
        Serum estradiol levels are not associated with urinary incontinence in midlife women transitioning through menopause.
        Menopause. 2011; 8: 1283-1290
        • Teleman P.M.
        • Persson J.
        • Mattiasson A.
        • Samsioe G.
        The relation between urinary incontinence and steroid hormone levels in perimenopausal women. A report from the Women's Health in the Lund Area (WHILA) study.
        Acta Obstetricia et Gynecologica Scandinavica. 2009; 88: 927-932
        • Cardozo L.
        • Lose G.
        • McClish D.
        • Versi E.
        A systematic review of the effects of estrogens for symptoms suggestive of overactive bladder.
        Acta Obstetricia et Gynecologica Scandinavica. 2004; 83: 892-897
        • Serati M.
        • Salvatore S.
        • Uccella S.
        • Cardozo L.
        • Bolis P.
        Is there a synergistic effect of topical oestrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity?.
        European Urology. 2009; 55: 713-719
        • Tseng L.H.
        • Wang A.C.
        • Chang Y.L.
        • Soong Y.K.
        • Lloyd L.K.
        • Ko Y.J.
        Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome.
        Neurourology and Urodynamics. 2009; 28: 47-51
        • Nelken R.S.
        • Ozel B.Z.
        • Leegant A.R.
        • Felix J.C.
        • Mishell D.R.
        Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder.
        Menopause. 2011; 18: 962-966
        • Sultana C.J.
        • Walters M.D.
        Estrogen and urinary incontinence in women.
        Maturitas. 1994; 20: 129-138
        • Hendrix S.L.
        • Cochrane B.B.
        • Nygaard I.E.
        • et al.
        Effects of estrogen with and without progestin on urinary incontinence.
        The journal of the American Medical Association. 2005; 293: 935-948
        • Steinauer J.E.
        • Waetjen L.E.
        • Vittinghoff E.
        • et al.
        Postmenopausal hormone therapy: does it cause incontinence?.
        Obstetrics and Gynecology. 2005; 106: 940-945
        • Cody J.D.
        • Richardson K.
        • Moehrer B.
        • Hextall A.
        • Glazener C.M.
        Oestrogen therapy for urinary incontinence in post-menopausal women.
        Cochrane Database of Systematic Reviews. 2009; : CD001405
        • Grodstein F.
        • Lifford K.
        • Resnick N.M.
        • Curhan G.C.
        Postmenopausal hormone therapy and risk of developing urinary incontinence.
        Obstetrics and Gynecology. 2004; 103: 254-260
        • Northington G.M.
        • de Vries H.F.
        • Bogner H.R.
        Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women.
        Menopause. 2012; 19: 290-295
        • Rud T.
        Urethral pressure profile in continent women from childhood to old age.
        Acta Obstetricia et Gynecologica Scandinavica. 1980; 59: 331-335
        • Jackson S.
        • Shepherd A.
        • Brookes S.
        • Abrams P.
        The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial.
        British Journal of Obstetrics and Gynaecology. 1999; 106: 711-718
        • Liapis A.
        • Bakas P.
        • Georgantopoulou C.
        • Creatsas G.
        The use of oestradiol therapy in postmenopausal women after TVT-O anti-incontinence surgery.
        Maturitas. 2010; 66: 101-106
        • Zullo M.A.
        • Plotti F.
        • Calcagno M.
        • et al.
        Vaginal estrogen therapy and overactive bladder symptoms in postmenopausal patients after a tension-free vaginal tape procedure: a randomized clinical trial.
        Menopause. 2005; 12: 421-427
        • Fritel X.
        • Ringa V.
        • Quiboeuf E.
        • Fauconnier A.
        Female urinary incontinence, from pregnancy to menopause, a review of epidemiologic and pathophysiologic findings.
        Acta Obstetricia et Gynecologica Scandinavica. 2012; 91: 901-910
        • Fritel X.
        • Fauconnier A.
        • Bader G.
        • et al.
        Diagnosis and management of adult female stress urinary incontinence: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians.
        European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2010; 151: 14-19
        • Thuroff J.W.
        • Abrams P.
        • Andersson K.E.
        • et al.
        EAU guidelines on urinary incontinence.
        European Urology. 2011; 59: 387-400