Abstract
Inherited bleeding disorders (IBDs) are by definition life-long. The commonest IBD
is von Willebrand disease (VWD), a deficiency of von Willebrand factor (VWF), with
a prevalence 1% in the general population and 13% in women with menorrhagia. Other
IBDs include carriers of haemophilia A (factor VIII deficiency) and haemophilia B,
(factor IX deficiency) and rare bleeding disorders (RBDs), deficiencies of factors
XI, X, V, VII, II, I and inherited platelet disorders. Diagnosis is the synthesis
of a bleeding history, family history and specialised laboratory tests. Women with
IBDs are more likely to suffer HMB, to be symptomatic, and to present with bleeding
in association with gynaecological problems. Heavy and/or abnormal menstrual bleeding
increases with age due increased anovulatory cycles and gynaecological pathologies
in older women. Thus, older women with IBDs are more likely to present with gynaecological
bleeding symptoms, have impaired QOL and require surgical interventions. Treatment
with specific clotting factor concentrates may be required and this requires an expert
in haematology. Awareness of IBDs among health care providers, early diagnosis and
appropriate management in a multidisciplinary approach is required to minimise the
bleeding complications for women with IBDs.
Keywords
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Article info
Publication history
Published online: March 05, 2012
Accepted:
February 17,
2012
Received:
February 9,
2012
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
