Abstract
Objective
The purpose of this study was to assess the effect of short-term aerobic training
on the fibrinolytic and coagulative factors in postmenopausal women.
Study design
Twenty volunteer sedentary healthy postmenopausal women (48–53 years), who entered
the menopause naturally, were divided randomly into two groups: training (n = 10) and control (n = 10).
Methods and main outcome measures
Training consisted of 10 sessions of submaximal aerobic cycling, 35 min for each session (5 min warm-up, 25 min aerobic training with 70% HRmax, 5 min active and 15 min passive recovery), 3 times a week. Coagulation and fibrinolytic factors were assessed
both before and after aerobic program in both groups.
Results
Fibrinogen, von Willbrand factor (vWF-Ag) antigen, plasminogen activator inhibitor-1
activity (PAI-1:Ac) and antigen (PAI-1:Ag) showed significant reduction after 10 sessions
in the training group (P < 0.05). Also after training, prothrombin time (PT), partial thromboplastin time (PTT),
tissue plasminogen activator activity (tPA:Ac) and antigen (tPA:Ag) increased (P < 0.05).
Conclusion
It was concluded that fibrinolytic activity on postmenopausal women could be improved
by a 3-week regular submaximal training program. These changes on the hemostatic factors
suggest that short-term aerobic training may prevent the decline in fibrinolytic function
observed in sedentary postmenopausal women.
Keywords
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Article info
Publication history
Published online: October 08, 2009
Accepted:
September 3,
2009
Received in revised form:
August 29,
2009
Received:
May 10,
2009
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
