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Are changes of prolactin levels the effectors of vitex agnus castus beneficial effects on the pre-menstrual syndrome?

      He and colleagues recently reported an interesting study showing that a vitex agnus castus (VAC) extract works as a safe, well tolerated, and effective drug for the treatment of pre-menstrual syndrome (PMS) [
      • He Z.
      • Chen R.
      • Zhou Y.
      • et al.
      Treatment for premenstrual syndrome with Vitex agnus castus: a prospective, randomized, multi-center placebo controlled study in China.
      ]. The biological mechanism by which the VAC therapeutic effects occurred is unknown. Many theories and hormonal alterations, including hyperprolactinemia, have been considered to explain PMS etiology but this issue has not been fully elucidated so far.

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      References

        • He Z.
        • Chen R.
        • Zhou Y.
        • et al.
        Treatment for premenstrual syndrome with Vitex agnus castus: a prospective, randomized, multi-center placebo controlled study in China.
        Maturitas. 2009; 63: 99-103
        • Jarry H.
        • Spengler B.
        • Wuttke W.
        • Christoffel V.
        In vitro assays for bioactivity-guided isolation of endocrine active compounds in vitex agnus-castus.
        Maturitas. 2006; 55: S26-36
        • Tamagno G.
        • Burlacu M.C.
        • Daly A.F.
        • Beckers A.
        Vitex agnus castus might enrich the pharmacological armamentarium for medical treatment of prolactinoma.
        Eur J Obstet Gynecol Reprod Biol. 2007; 135: 139-140
        • Kilicdag E.B.
        • Tarim E.
        • Bagis T.
        • et al.
        Fructus agni casti and bromocriptine for treatment of hyperprolactinemia and mastalgia.
        Int J Gynaecol Obstet. 2004; 85: 292-293
        • Merz P.G.
        • Gorkow C.
        • Schrödter A.
        • et al.
        The effects of a special agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects.
        Exp Clin Endocrinol Diabetes. 1996; 104: 447-453