We read with great interest the article by Schnatz et al. [
[1]
] in which they showed that hormonal therapy is associated with a lower prevalence
of breast arterial calcification (BAC) on mammography while well-established risk
factors (diabetes, stroke, and age) appear to be associated with significantly higher
incidence of BAC. However, history of bisphosphonate use may also influence prevalence
of BAC on these patients. Bisphosphonates are the first-line drugs for treating postmenopausal
women with osteoporosis. Alendronate and risedronate reduce the risk of both vertebral
and nonvertebral fractures. We previously suggest that bisphosphonate use for osteoporosis
in postmenopausal women may inhibit occurrence of malignant microcalcification in
breast tissue and development of atherosclerosis formation through its bactericidal
effect on nanobacteria [
2
,
3
]. In the light of above information bisphosphonate use may also lead to lower prevalence
of BAC on mammography.To read this article in full you will need to make a payment
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References
- Hormonal therapy is associated with a lower prevalence of breast arterial calcification on mammography.Maturitas. 2007; ([Epub ahead of print])
- Bisphosphonate use for osteoporosis in postmenopausal women may inhibit occurrence of malignant microcalcification in breast tissue.Med Hypotheses. 2006; 67: 202-203
- Bisphosphonates may inhibit development of atherosclerosis formation through its bactericidal effect on nanobacteria.Med Hypotheses. 2005; 64: 1239-1240
Article info
Publication history
Published online: October 04, 2007
Received:
May 28,
2007
Identification
Copyright
© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
