Osteoporosis and increased pulse wave velocity (PWV) are cardiovascular risk factors. We investigated the relationship between PWV and bone mass in the lumbar spine in postmenopausal women.
We studied the PWV in 95 women; 38 postmenopausal women with normal spinal bone mineral density (BMD), 32 osteopenic postmenopausal women, and 25 osteoporotic postmenopausal women. The brachial-ankle PWV (baPWV) was measured using an automated device. The BMD of the lumbar spine (L2–L4) was measured using dual-energy X-ray absorptiometry.
After adjusting for age and years since menopause, women with osteoporosis had a significantly higher baPWV than those with normal BMD (1500 ± 220 cm/s versus 1340 ± 215 cm/s; P < 0.05), but no significant differences in baPWV were seen between the osteoporotic and osteopenic groups or between the osteopenic and normal BMD groups. In univariate regression analysis, the baPWV was significantly negatively correlated with BMD (r = −0.450, P < 0.01), and significantly positively correlated with age (r = 0.601, P < 0.01), years since menopause (r = 0.577, P < 0.01), systolic blood pressure (r = 0.295, P < 0.01), and diastolic blood pressure (r = 0.264, P < 0.05), but was not with other variables. In multivariate regression analysis, the baPWV was significantly correlated with BMD (P < 0.05), but not with other variables.
Postmenopausal women with osteoporosis may have elevated arterial stiffness, suggesting that osteoporotic postmenopausal women may have a higher risk of cardiovascular disease.
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- The association between low bone mass at the menopause and cardiovascular mortality.Am J Med. 1999; 106: 273-278
- Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association Writing Group.Circulation. 1997; 96: 2468-2482
- The worldwide problem of osteoporosis: insights afforded by epidemiology.Bone. 1995; 17: 505S-511S
- Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women.Calcif Tissue Int. 1998; 62: 209-213
- Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study.Arterioscler Thromb Vasc Biol. 2000; 20: 1926-1931
- Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia.J Clin Endocrinol Metab. 2003; 88: 2573-2578
- Low bone mineral density is related to echogenic carotid artery plaques: a population-based study.Am J Epidemiol. 2004; 160: 549-556
- Forearm endothelial function and bone mineral loss in postmenopausal women.Atherosclerosis. 2004; 176: 387-392
- Non-invasive assessment of cardiovascular disease in diabetes mellitus.Lancet. 1997; 350: 14-19
- Assessment of arterial distensibility by automatic pulse wave velocity measurement: validation and clinical application studies.Hypertension. 1995; 26: 485-490
- Smooth muscle relaxation: effects on arterial compliance, distensibility, elastic modulus, and pulse wave velocity.Hypertension. 1998; 32: 356-359
- Vascular wall function as a risk marker for cardiovascular disease.J Hypertens. 1999; 17: S41-S44
- Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.Hypertension. 2001; 37: 1236-1241
- Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement.Hypertens Res. 2002; 25: 359-364
- J Jpn Atheroscler Soc. 1997; 25: 1-34
- The diagnosis of osteoporosis.J Bone Miner Res. 1994; 9: 1137-1141
- Pathogenesis of bone fragility in women and men.Lancet. 2002; 359: 1841-1850
- Sex steroids and the construction and conservation of the adult skeleton.Endocr Rev. 2002; 23: 279-302
- Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study.Atherosclerosis. 2002; 160: 441-448
- Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association Writing Group.Circulation. 1996; 94: 1175-1192
- Sex hormones and coronary disease: a review of the clinical studies.Steroids. 1990; 55: 330-352
- Factors associated with appendicular bone mass in older women: the Study of Osteoporotic Fractures Research Group.Ann Intern Med. 1993; 118: 657-665
- Evidence of estrogen receptors in normal human osteoblast-like cells.Science. 1988; 241: 84-86
- Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.Proc Natl Acad Sci USA. 1994; 91: 5227-5231
- The protective effects of estrogen on the cardiovascular system.N Engl J Med. 1999; 340: 1801-1811
- The effect of postmenopausal estrogen therapy on bone density in elderly women.N Engl J Med. 1993; 329: 1141-1146
- Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial.JAMA. 1996; 276: 1389-1396
- The effect of hormone replacement therapy on arterial blood pressure and vascular compliance in postmenopausal women with arterial hypertension.J Hum Hypertens. 2002; 16: 509-516
- Primary hyperparathyroidism: incidence of cardiac abnormalities and partial reversibility after successful parathyroidectomy.Am J Med. 1993; 95: 197-202
- Role of oxidized low density lipoprotein in atherogenesis.J Clin Invest. 1991; 88: 1785-1792
- Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: a possible explanation for the paradox of arterial calcification in osteoporotic patients.Arterioscler Thromb Vasc Biol. 1997; 17: 680-687
- Increased plasma homocysteine after menopause.Atherosclerosis. 2000; 149: 163-168
- The natural history of homocystinuria due to cystathionine beta-synthase deficiency.Am J Hum Genet. 1985; 37: 1-31
- Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.J Clin Invest. 1993; 92: 1686-1696
- High expression of genes for calcification-regulating proteins in human atherosclerotic plaques.J Clin Invest. 1994; 93: 2393-2402
- Relation of low bone mineral density and carotid atherosclerosis in postmenopausal women.Am J Cardiol. 2004; 94: 266-269
- Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease.Circulation. 2002; 106: 1192-1194
Accepted: February 28, 2006
Received in revised form: February 27, 2006
Received: July 13, 2005
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.