Abstract
Objectives
Osteoporosis and increased pulse wave velocity (PWV) are cardiovascular risk factors.
We investigated the relationship between PWV and bone mass in the lumbar spine in
postmenopausal women.
Methods
We studied the PWV in 95 women; 38 postmenopausal women with normal spinal bone mineral
density (BMD), 32 osteopenic postmenopausal women, and 25 osteoporotic postmenopausal
women. The brachial-ankle PWV (baPWV) was measured using an automated device. The
BMD of the lumbar spine (L2–L4) was measured using dual-energy X-ray absorptiometry.
Results
After adjusting for age and years since menopause, women with osteoporosis had a significantly
higher baPWV than those with normal BMD (1500 ± 220 cm/s versus 1340 ± 215 cm/s; P < 0.05), but no significant differences in baPWV were seen between the osteoporotic
and osteopenic groups or between the osteopenic and normal BMD groups. In univariate
regression analysis, the baPWV was significantly negatively correlated with BMD (r = −0.450, P < 0.01), and significantly positively correlated with age (r = 0.601, P < 0.01), years since menopause (r = 0.577, P < 0.01), systolic blood pressure (r = 0.295, P < 0.01), and diastolic blood pressure (r = 0.264, P < 0.05), but was not with other variables. In multivariate regression analysis, the
baPWV was significantly correlated with BMD (P < 0.05), but not with other variables.
Conclusions
Postmenopausal women with osteoporosis may have elevated arterial stiffness, suggesting
that osteoporotic postmenopausal women may have a higher risk of cardiovascular disease.
Keywords
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Article info
Publication history
Accepted:
February 28,
2006
Received in revised form:
February 27,
2006
Received:
July 13,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
