Abstract
Objectives
We evaluated whether tibolone had an adverse effect on the progression free survival
and overall survival of epithelial ovarian cancer patients.
Methods
Forty-two tibolone users and 33 non-users who had been surgically managed for epithelial
ovarian cancer at Gil Medical Center, Inchon, Korea, from January 1997 to December
2003 were reviewed retrospectively.
Results
There were no statistically significant differences in age, stage, histology, grade
and surgical optimality between tibolone users and non-users. The progression free
survival at 36 months was 60.0% among the users compared with 61.5% among the non-users
(p = 0.92). There was also no significant difference in the overall survival between two
groups (p = 0.30). For stage IIIc patients according to tibolone using, there were no significant
differences in the progression free survival (p = 0.86) and overall survival (p = 0.36) between tibolone users and non-users.
Conclusions
There was no evidence that tibolone had detrimental effects on the progression free
survival and overall survival of epithelial ovarian cancer patients. So, tibolone
could be used in these patients.
Keywords
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Article info
Publication history
Accepted:
January 25,
2006
Received in revised form:
January 20,
2006
Received:
August 8,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
