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Alcohol, caffeine and smoking in relation to age at menopause

  • Ann Kinney
    Correspondence
    Corresponding author at: Epidemiology, Room 1607, 722 West 168th Street, New York, NY 10032, USA. Tel.: +1 212 305 9110; fax: +1 212 305 4653.
    Affiliations
    Department of Epidemiology, Graduate School of Arts and Sciences, Columbia University, New York, NY, USA

    Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY, USA
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  • Jennie Kline
    Affiliations
    Epidemiology of Developmental Brain Disorders Department, New York State Psychiatric Institute, New York, NY, USA

    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
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  • Bruce Levin
    Affiliations
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA
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      Abstract

      Objectives

      Exposures which might influence age at natural menopause have been extensively studied but, with the exception of cigarette smoking, results have been inconsistent. We sought to determine: (i) whether alcohol and caffeine intake are associated with age at menopause; (ii) whether the association of cigarette smoking with age at menopause is confined to current smokers.

      Methods

      Analyses drew on longitudinal data from 494 women, aged 44–60 in 1993, of whom 159 experienced menopause before intake or during follow-up. We used parametric logistic survival analysis to estimate shifts in median age at menopause for women who drink alcohol or caffeine or who smoke cigarettes.

      Results

      The estimated median age at menopause was 2.2 (95% confidence interval (CI) 0.5, 3.9) years later for women who drank alcohol 5–7 days/week (13% of the sample) than for women who did not drink alcohol (54%). For women who drank at least 1 day/week, the estimated shift was 1.3 (95% CI 0.2, 2.3) years. Caffeine intake in approximate quartiles of mg/day—0–100, >100–200, >200–400, 400+—was not related to age at menopause. Current smokers of 14+ cigarettes/day (6%) experienced menopause 2.8 (95% CI −4.8, −0.8) years earlier than women who never smoked (51%). Current smokers of 1–13 cigarettes/day (5%) and former smokers (38%) experienced menopause at about the same age as women who never smoked.

      Conclusions

      The results are compatible with a pro-estrogenic effect of moderate alcohol intake and an anti-estrogenic effect of current cigarette smoking of 14+ cigarettes/day.

      Keywords

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