Abstract
Objectives
Exposures which might influence age at natural menopause have been extensively studied
but, with the exception of cigarette smoking, results have been inconsistent. We sought
to determine: (i) whether alcohol and caffeine intake are associated with age at menopause;
(ii) whether the association of cigarette smoking with age at menopause is confined
to current smokers.
Methods
Analyses drew on longitudinal data from 494 women, aged 44–60 in 1993, of whom 159
experienced menopause before intake or during follow-up. We used parametric logistic
survival analysis to estimate shifts in median age at menopause for women who drink
alcohol or caffeine or who smoke cigarettes.
Results
The estimated median age at menopause was 2.2 (95% confidence interval (CI) 0.5, 3.9)
years later for women who drank alcohol 5–7 days/week (13% of the sample) than for women who did not drink alcohol (54%). For
women who drank at least 1 day/week, the estimated shift was 1.3 (95% CI 0.2, 2.3) years. Caffeine intake in
approximate quartiles of mg/day—0–100, >100–200, >200–400, 400+—was not related to
age at menopause. Current smokers of 14+ cigarettes/day (6%) experienced menopause 2.8 (95% CI −4.8, −0.8) years earlier than
women who never smoked (51%). Current smokers of 1–13 cigarettes/day (5%) and former smokers (38%) experienced menopause at about the same
age as women who never smoked.
Conclusions
The results are compatible with a pro-estrogenic effect of moderate alcohol intake
and an anti-estrogenic effect of current cigarette smoking of 14+ cigarettes/day.
Keywords
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Article info
Publication history
Accepted:
October 4,
2005
Received in revised form:
September 26,
2005
Received:
August 8,
2005
Identification
Copyright
© 2005 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.