Abstract
Tibolone is a tissue-selective compound used for the treatment of climacteric symptoms
and the prevention of osteoporosis in post-menopausal women. In this review some in
vitro data and clinical studies indicating that the effects of tibolone on breast
tissue are different from those seen with oestrogen-based hormone therapy (HT) are
briefly discussed. From a clinical perspective, an increase in mammographic density
and breast cell proliferation should be regarded as an unwanted side-effect of HT.
Efforts should therefore be made to define treatment regimens for post-menopausal
women that have minimal effects on the breast but still maintain the many advantages
of HT. Data suggest that tibolone may be such an alternative.
Keywords
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Article info
Publication history
Accepted:
June 17,
2004
Received in revised form:
May 6,
2004
Received:
January 12,
2004
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
