The use of hormone replacement therapy worldwide has declined since the WHI combined
HRT trial reported an increased risk of breast cancer on combined oestrogen and progesterone
HRT [
[1]
]. Shortly afterwards in 2003 the Million Women Study [
[2]
], a retrospective/prospective epidemiological cohort study reported a similar finding
with not only combined HRT but also oestrogen alone HRT and tibolone showing an increased
risk of breast cancer. The more recent oestrogen only WHI Study reported no increased
risk of breast cancer on therapy [R2 = 0.77 (0.59–1.01)] and underlined the importance and level of evidence obtained
from randomised clinical trials [
[3]
] but unfortunately in the public eye the reputation of all types of HRT has been tarnished.To read this article in full you will need to make a payment
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References
- WHI Investigators. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the women’s health initiative randomized trial.JAMA. 2003; 289: 3243-3253
- Million Women Study Collaborators. Breast cancer and hormone replacement therapy in the Million Women Study.Lancet. 2003; 362: 419-427
- Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial.JAMA. 2004; 291: 1701-1712
- Effects of tibolone and continuous combined hormone therapy on mammographic breast density and breast histochemical markers in postmenopausal women.Fertil. Steril. 2004; 81: 617-623
Article info
Publication history
Received:
June 8,
2004
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
