Abstract
Objectives: To investigate the therapeutic effect of combined use of vitamin K2 and D3 on vertebral bone mineral density in postmenopausal women with osteopenia and osteoporosis.
Subjects and methods: We enrolled 172 women with vertebral bone mineral density <0.98 g/cm2 (osteopenia and osteoporosis) as measured by dual-energy X-ray absorptiometry. In
this study, we employed the criteria for diagnosis of osteopenia and osteoporosis
using dual energy X-ray absorptiometry proposed by the Japan Society of Bone Metabolism
in 1996. Subjects were randomized into four groups (each having 43 subjects in vitamin
K2 therapy group, vitamin D3 therapy group, vitamin K2 and D3 combined therapy group, or a control group receiving dietary therapy alone) and treated
with respective agents for 2 years, with bone mineral density was measured prior to
therapy and after 6, 12, 18, and 24 months of treatment. The bone metabolism markers
analyzed were serum type 1 collagen carboxyterminal propeptide (P1CP), serum intact
osteocalcin, and urinary pyridinoline. Tests of blood coagulation function consisted
of measurement of activated partial thromboplastin time (APTT) and analysis of concentrations
of antithrombin III (AT III), fibrinogen, and plasminogen. Results: Combined therapy with vitamin K2 and D3 for 24 months markedly increased bone mineral density (4.92±7.89%), while vitamin
K2 alone increased it only 0.135±5.44%. The bone markers measured, revealed stimulation
of both bone formation and resorption activity. We observed an increase in coagulation
and fibrinolytic activity that was within the normal range, suggesting that balance
was maintained in the fibrinolysis–coagulation system. Conclusions: Continuous combination therapy with vitamin K2 and D3 may be useful for increasing vertebral bone mass in postmenopausal women. Furthermore,
the increase in coagulation function observed during this therapy was within the physiological
range, and no adverse reactions were observed.
Keywords
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Article Info
Publication History
Accepted:
September 14,
2001
Received in revised form:
February 7,
2001
Received:
July 28,
2000
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
