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Percutaneous absorption of progesterone

      Topical progesterone creams and gels have been successfully used for treating menopausal related symptoms and conditions, but their widespread acceptance as standard of care for preventing estrogen-stimulated cell proliferation has been hampered because it results in very little increase in serum progesterone levels. Instead, FDA-approved oral progesterone therapy has remained the mainstay of conventional progesterone therapy for countering estrogen-stimulated proliferation of the endometrium. Venipuncture serum is considered the gold standard for testing sex-steroid hormone levels in the body. It is widely believed that progesterone is poorly absorbed through the skin based on pharmacokinetic studies showing that only about 10% of progesterone delivered topically is detected in serum.
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