Advertisement
Review| Volume 73, ISSUE 4, P312-317, December 2012

Download started.

Ok

Exercise and longevity

  • Vincent Gremeaux
    Affiliations
    Cardiovascular Prevention and Rehabilitation Center (Centre ÉPIC), Montreal Heart Institute, Montreal, Quebec, Canada

    Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

    Department of Medicine, Université de Montréal, Montreal, Québec, Canada

    Pôle Rééducation-Réadaptation, CHU Dijon, France

    INSERM, U1093 “Cognition, Action, et Plasticité Sensorimotrice”, Dijon, F-21078, France

    Plateforme d’Investigation Technologique du Centre d’Investigation Clinique Plurithématique INSERM 803, CHU Dijon, France
    Search for articles by this author
  • Mathieu Gayda
    Affiliations
    Cardiovascular Prevention and Rehabilitation Center (Centre ÉPIC), Montreal Heart Institute, Montreal, Quebec, Canada

    Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

    Department of Medicine, Université de Montréal, Montreal, Québec, Canada
    Search for articles by this author
  • Romuald Lepers
    Affiliations
    INSERM, U1093 “Cognition, Action, et Plasticité Sensorimotrice”, Dijon, F-21078, France
    Search for articles by this author
  • Philippe Sosner
    Affiliations
    Cardiovascular Prevention and Rehabilitation Center (Centre ÉPIC), Montreal Heart Institute, Montreal, Quebec, Canada

    Service de Cardiologie, CHU de Poitiers, France

    Laboratoire MOVE EA 3813, Faculté des Sciences du Sport, Université de Poitiers, France

    Inserm CIC-P 802, CHU de Poitiers, France
    Search for articles by this author
  • Martin Juneau
    Affiliations
    Cardiovascular Prevention and Rehabilitation Center (Centre ÉPIC), Montreal Heart Institute, Montreal, Quebec, Canada

    Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

    Department of Medicine, Université de Montréal, Montreal, Québec, Canada
    Search for articles by this author
  • Anil Nigam
    Correspondence
    Corresponding author at: Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec,H1T 1C8 Canada. Tel.: +1 514 376 3330x4033; fax: +1 514 376 1355.
    Affiliations
    Cardiovascular Prevention and Rehabilitation Center (Centre ÉPIC), Montreal Heart Institute, Montreal, Quebec, Canada

    Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada

    Department of Medicine, Université de Montréal, Montreal, Québec, Canada
    Search for articles by this author

      Abstract

      Aging is a natural and complex physiological process influenced by many factors, some of which are modifiable. As the number of older individuals continues to increase, it is important to develop interventions that can be easily implemented and contribute to “successful aging”. In addition to a healthy diet and psychosocial well-being, the benefits of regular exercise on mortality, and the prevention and control of chronic disease affecting both life expectancy and quality of life are well established. We summarize the benefits of regular exercise on longevity, present the current knowledge regarding potential mechanisms, and outline the main recommendations. Exercise can partially reverse the effects of the aging process on physiological functions and preserve functional reserve in the elderly. Numerous studies have shown that maintaining a minimum quantity and quality of exercise decreases the risk of death, prevents the development of certain cancers, lowers the risk of osteoporosis and increases longevity. Training programs should include exercises aimed at improving cardiorespiratory fitness and muscle function, as well as flexibility and balance. Though the benefits of physical activity appear to be directly linked to the notion of training volume and intensity, further research is required in the elderly, in order to develop more precise recommendations, bearing in mind that the main aim is to foster long-term adherence to physical activity in this growing population.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Maturitas
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Glatt S.J.
        • Chayavichitsilp P.
        • Depp C.
        • et al.
        Successful aging: from phenotype to genotype.
        Biological Psychiatry. 2007; 62: 282-293
        • Lupien S.
        • Wan N.
        Successful aging: from cell to self.
        Philosphical Transactions of the Royal Society of London. Series B, Biological Sciences. 2004; 359: 1413-1426
        • Rowe J.
        • Kahn R.
        Successful Aging.
        Aging. 1998; 10: 142-144
        • Fleg J.
        • Morrell C.H.
        • Bos A.G.
        • et al.
        Accelerated longitudinal decline of aerobic capacity in healthy older adults.
        Circulation. 2005; 112: 674-682
        • Janssen I.
        Influence of sarcopenia on the development of physical disability: the cardiovascular health study.
        Journal of the American Geriatrics Society. 2006; 54: 56-62
        • Sui X.
        • Lamonte M.J.
        • Laditka J.N.
        • et al.
        Cardiorespiratory fitness and adiposity as mortality predictors in older adults.
        JAMA: The Journal of the American Medical Association. 2007; 298.: 2507-2516
        • Nelson M.E.
        • Rejeski W.J.
        • Blair S.N.
        • et al.
        Physical activity and public health in older adults: recommendation from the American college of sports medicine and the American heart association.
        Circulation. 2007; 116: 1094-1105
        • Charles M.
        • Charifi N.
        • Verney J.
        • et al.
        Effect of endurance training on muscle microvascular filtration capacity and vascular bed morphometry in the elderly.
        Acta Physiologica (Oxford, England). 2006; 187: 399-406
        • Kent-Braun J.A.
        • Ng A.V.
        • Young K.
        Skeletal muscle contractile and noncontractile components in young and older women and men.
        Journal of Applied Physiology. 2000; 88: 662-668
        • Lexell J.
        Ageing and human muscle: observations from Sweden.
        Canadian Journal of Applied Physiology. 1993; 18: 2-18
        • Sayer A.A.
        • Syddall H.
        • Martin H.
        • et al.
        The developmental origins of sarcopenia.
        Journal of Nutrition, Health and Aging. 2008; 12: 427-432
        • Fleck S.
        • Kraemer J.
        Designing resistance training programs.
        Human Kinetics, Champaign, IL2006
        • Klitgaard H.
        • Mantoni M.
        • Schiaffino S.
        • et al.
        Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds.
        Acta Physiologica Scandinavica. 1990; 140: 41-54
        • Young A.
        • Stokes M.
        • Crowe M.
        The size and strength of the quadriceps muscles of old and young men.
        Clinical Physiology. 1985; 5: 145-154
        • Rantanen T.
        • Guralnik J.M.
        • Foley D.
        • et al.
        Midlife hand grip strength as a predictor of old age disability.
        JAMA: The Journal of the American Medical Association. 1999; 281: 558-560
        • Rantanen T.
        • Guralnik J.M.
        • Sakari-Rantala R.
        • et al.
        Disability, physical activity, and muscle strength in older women: the women's health and aging study.
        Archives of Physical Medicine and Rehabilitation. 1999; 80: 130-135
        • Lanyon L.
        • Skerry T.
        Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis.
        Journal of Bone and Mineral Research. 2001; 16: 1937-1947
        • Rubin C.T.
        • Bain S.D.
        • McLeod K.J.
        Suppression of the osteogenic response in the aging skeleton.
        Calcified Tissue International. 1992; 50: 306-313
        • Ahmed T.
        • Haboubi N.
        Assessment and management of nutrition in older people and its importance to health.
        Clincal Interventions in Aging. 2010; 5: 207-216
        • Hank K.
        How “successful” do older Europeans age? Findings from SHARE.
        The Journals of Gerontology Series B, Psychological Sciences and Social Sciences. 2011; 66: 230-236
        • INSERM
        Activité physique: contextes et effets sur la santé. Expertise collective.
        Les Éditions Inserm, Paris2008
        • Nocon M.
        • Hiemann T.
        • Muller-Riemenschneider F.
        • et al.
        Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis.
        European Journal of Cardiovascular Prevention and Rehabilitation. 2008; 15: 239-246
        • Apullan F.J.
        • Bourassa M.G.
        • Tardif J.C.
        • et al.
        Usefulness of self-reported leisure-time physical activity to predict long-term survival in patients with coronary heart disease.
        American Journal of Cardiology. 2008; 102: 375-379
        • Taylor R.
        • Brown A.
        • Ebrahim S.
        • et al.
        Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials.
        American Journal of Medicine. 2004; 15: 682-692
        • Paffenbarger Jr., R.S.
        • Hyde R.T.
        • Wing A.L.
        • et al.
        Physical activity, all-cause mortality, and longevity of college alumni.
        New England Journal of Medicine. 1986; 314: 605-613
        • Franco O.H.
        • de Laet C.
        • Peeters A.
        • et al.
        Effects of physical activity on life expectancy with cardiovascular disease.
        Archives of Internal Medicine. 2005; 165: 2355-2360
        • Lollgen H.
        • Bockenhoff A.
        • Knapp G.
        Physical activity and all-cause mortality: an updated meta-analysis with different intensity categories.
        International Journal of Sports Medicine. 2009; 30: 213-224
        • Samitz G.
        • Egger M.
        • Zwahlen M.
        Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies.
        International Journal of Epidemiology. 2011; 40: 1382-1400
        • Kujala U.M.
        • Kaprio J.
        • Sarna S.
        • et al.
        Relationship of leisure-time physical activity and mortality: the Finnish twin cohort.
        JAMA: The Journal of the American Medical Association. 1998; 279: 440-444
        • Grimsmo J.
        • Maehlum S.
        • Moelstad P.
        • et al.
        Mortality and cardiovascular morbidity among long-term endurance male cross country skiers followed for 28–30 years.
        Scandinavian Journal of Medicine and Science in Sports. 2011; 21: pe351-pe358
        • Sanchis-Gomar F.
        • Olaso-Gonzalez G.
        • Corella D.
        • et al.
        Increased average longevity among the “Tour de France” cyclists.
        International Journal of Sports Medicine. 2011; 32: 644-647
        • Taraldsen K.
        • Chastin S.F.
        • Riphagen I.
        • et al.
        Physical activity monitoring by use of accelerometer-based body-worn sensors in older adults: a systematic literature review of current knowledge and applications.
        Maturitas. 2012; 71: 13-19
        • Aoyagi Y.
        • Shephard R.J.
        Habitual physical activity and health in the elderly: the Nakanojo study.
        Geriatrics Gerontology International. 2010; 10: S236-S243
        • Tudor-Locke C.
        • Craig C.L.
        • Aoyagi Y.
        • et al.
        How many steps/day are enough? For older adults and special populations.
        International Journal of Behavioral Nutritions and Physical Activity. 2011; 8: p80
        • Juneau M.
        • Nigam A.
        Exercise training after an acute coronary syndrome, in acute coronary syndromes: a companion to Braunwald's heart disease.
        Saunders, Philadelphia2003
        • Stathokostas L.
        • Jacob-Johnson S.
        • Petrella R.J.
        • et al.
        Longitudinal changes in aerobic power in older men and women.
        Journal of Applied Physiology. 2004; 97: 781-789
        • Vogel T.
        • Brechat P.H.
        • Leprêtre P.M.
        • et al.
        Health benefits of physical activity in older patients: a review.
        International Journal of Clinical Practice. 2009; 63: 303-320
        • Wilson T.M.
        • Tanaka H.
        Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status.
        American Journal of Physiology Heart and Circulatory Physiology. 2000; 278: H829-H834
        • Mazzeo R.S.
        • Tanaka H.
        Exercise prescription for the elderly: current recommendations.
        Sports Medicine. 2001; 31: 809-818
        • Vaitkevicius P.V.
        • Ebersold C.
        • Shah M.S.
        • et al.
        Effects of aerobic exercise training in community-based subjects aged 80 and older: a pilot study.
        Journal of the American Geriatrics Society. 2002; 50: 2009-2013
        • Lepers R.
        • Cattagni T.
        Do older athletes reach limits in their performance during marathon running?.
        Age (Dordrecht). 2012; 34: 773-781
        • Tanaka H.
        • Seals D.R.
        Endurance exercise performance in masters athletes: age-associated changes and underlying physiological mechanisms.
        Journal of Physiology. 2008; 586: 55-63
        • Hagerman F.C.
        • Walsh S.J.
        • Staron R.S.
        • et al.
        Effects of high-intensity resistance training on untrained older men I. Strength, cardiovascular, and metabolic responses.
        Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2000; 55: B336-B346
        • Harris C.
        • DeBeliso M.A.
        • Spitzer-Gibson T.A.
        • et al.
        The effect of resistance-training intensity on strength-gain response in the older adult.
        Journal of Strength and Conditioning Research. 2004; 18: 833-838
        • Narici M.V.
        • Reeves N.D.
        • Morse C.I.
        • et al.
        Muscular adaptations to resistance exercise in the elderly.
        Journal of Musculoskeletal & Neuronal Interactions. 2004; 4: 161-164
        • Miszko T.A.
        • Cress M.E.
        • Slade J.M.
        • et al.
        Effect of strength and power training on physical function in community-dwelling older adults.
        Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2003; 58: 171-175
        • Porter M.M.
        Power training for older adults.
        Applied Physiology, Nutrition, and Metabolism. 2006; 31: 87-94
        • Peterson M.D.
        • Rhea M.R.
        • Sen A.
        • et al.
        Resistance exercise for muscular strength in older adults: a meta-analysis.
        Ageing Research Reviews. 2010; 9: 226-237
        • Paterson D.
        • Jones G.
        • Rice C.
        Aging and physical activity data on which to base recommendations for exercise in older adults.
        Applied Physiology, Nutrition, and Metabolism. 2007; 32: S75-S171
        • Porter M.M.
        The effects of strength training on sarcopenia.
        Canadian Journal of Applied Physiology. 2001; 26: 123-141
        • Grabiner M.D.
        • Enoka R.M.
        Changes in movement capabilities with aging.
        Exercise and Sport Sciences Reviews. 1995; 23: 65-104
        • Yarasheski K.E.
        Exercise, aging, and muscle protein metabolism.
        Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2003; 58: M918-M922
        • Bailey C.A.
        • Brooke-Wavell K.
        Exercise for optimising peak bone mass in women.
        Proceedings of the Nutrition Society. 2008; 67: 9-18
        • Kohrt W.M.
        • Bloomfield S.A.
        • Little K.D.
        • et al.
        American college of sports medicine position stand: physical activity and bone health.
        Medicine and Science in Sports and Exercise. 2004; 36: 1985-1996
        • Rubin J.
        • Murphy T.C.
        • Zhu L.
        • et al.
        Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK.
        Journal of Biological Chemistry. 2003; 278: 34018-34025
        • Saunders M.M.
        • Taylor A.F.
        • Du C.
        • et al.
        Mechanical stimulation effects on functional end effectors in osteoblastic MG-63 cells.
        Journal of Biomechanics. 2006; 39: 1419-1427
        • Boyce B.F.
        • Xing L.
        Functions of RANKL/RANK/OPG in bone modeling and remodeling.
        Archives of Biochemistry and Biophysics. 2008; 473: 139-146
        • Howe T.E.
        • Shea B.
        • Dawson L.J.
        • et al.
        Exercise for preventing and treating osteoporosis in postmenopausal women.
        Cochrane Database of Systematic Reviews. 2011; 7: CD000333
        • Hamilton C.J.
        • Swan V.J.
        • Jamal S.A.
        The effects of exercise and physical activity participation on bone mass and geometry in postmenopausal women: a systematic review of pQCT studies.
        Osteoporosis International. 2010; 21: 11-23
        • Cherkas L.F.
        • Hunkin J.L.
        • Kato B.S.
        • et al.
        The association between physical activity in leisure time and leukocyte telomere length.
        Archives of Internal Medicine. 2008; 168: 154-158
        • Ownby R.L.
        Medication adherence and cognition medical, personal and economic factors influence level of adherence in older adults.
        Geriatrics. 2006; 61: 30-35
        • Strandberg T.E.
        • Pitkala K.H.
        • Tilvis R.S.
        Predictors of mortality in home-dwelling patients with cardiovascular disease aged 75 and older.
        Journal of the American Geriatrics Society. 2009; 57: 279-284
        • Chang Y.K.
        • Labban J.D.
        • Gapin J.I.
        • et al.
        The effects of acute exercise on cognitive performance: a meta-analysis.
        Brain Research. 2012; 1453: 87-101
        • Tseng C.N.
        • Gau B.S.
        • Lou M.F.
        The effectiveness of exercise on improving cognitive function in older people: a systematic review.
        Journal of Nursing Research. 2011; 19: 119-131
        • Wen C.P.
        • Wai J.P.
        • Tsai M.K.
        • et al.
        Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study.
        Lancet. 2011; 378: 1244-1253
        • Nigam A.
        • Juneau M.
        Survival benefit associated with low-level physical activity.
        Lancet. 2011; 378: 1202-1203