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Abstract
Oestrogen plays a role in modulating growth hormone (GH), luteinizing hormone (LH),
folliclestimulating hormone (FSH) and osteocalcin secretion in women. Indeed, the
postmenopausal period is characterized by changes in plasma GH, LH, FSH and osteocalcin
levels. The aim of the present study was to investigate the changes in the secretory
patterns of these hormones in postmenopausal women under different therapeutic regimens.
A total of 20 subjects took part in the study. They were subdivided into four groups
comprising 5 untreated postmenopausal women (time since menopause 1–5 years), 5 postmenopausal
women receiving steroid hormone replacement therapy, 5 postmenopausal women receiving
salmon calcitonin and 5 fertile women with regular menstrual cycles. Blood samples
were collected every 15 min for 4 h and hormone levels were measured by radioimmunoassay.
Plasma GH levels fell in the postmenopausal women, but were restored under oestrogen-progestogen
treatment. The pulsatile patterns of plasma LH and FSH did not show significant differences
in the treated and untreated women. Plasma osteocalcin levels showed episodic fluctuations
and mean levels decreased under steroid hormone or calcitonin treatment. No significant
correlation was observed between plasma GH and osteocalcin or gonadotrophin levels
or body mass index.
Keywords
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Article info
Publication history
Accepted:
June 26,
1992
Received in revised form:
June 22,
1992
Received:
April 1,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
